CD97 Protein & Antibody

Cluster of Differentiation 97

CD97 Products

CD97 Protein, Recombinant

Molecule	Species	Description	Cat. No
CD97	Human	CD97/Fc Protein, Recombinant	11280-H02H
CD97	Human	CD97 Protein, Recombinant	11280-H08H

  11280-H02H: Immobilized human CD55 at 2 µg/ml (100 µl/well) can bind human CD97 with a linear ranger of 1.28-32 ng/ml. Measured by its binding ability in a functional ELISA.

  11280-H08H:  Immobilized recombinant human CD97 at 10 µg/ml (100 µl/well) can bind recombinant human CD55 at a linear range of 0.46-30 µg/ml. Measured by its binding ability in a functional ELISA.

CD97 Antibody

Molecule	Application	Description	Cat. No
Human CD97	WB, ELISA	Mouse Monoclonal Antibody	11280-MM05
Human CD97	WB, FCM	CD97 Antibody ( FITC )	11280-MM03-F
Human CD97	WB, ELISA	CD97 Antibody, Rabbit MAb	11280-R024
Human CD97	WB, ELISA	CD97 Antibody, Rabbit PAb	11280-RP01
Human CD97	WB, ELISA	CD97 Antibody, Rabbit PAb (Antigen Affinity Purified)	11280-RP02

CD97 ELISA Kit

Molecule	Application	Description	Cat. No
Human CD97	ELISA	CD97 ELISA Kit	SEK11280

CD97 cDNA Clone

Molecule	Species	Description	Cat. No
CD97	Human	Homo sapiens CD97 cDNA Clone (NM_078481.2)	HG11280-M
CD97	Mouse	Mouse CD97 cDNA Clone / ORF Clone	MG50751-G

CD97 Related Areas

Immunology>>Cluster of Differentiation>>Other>>CD97

CD97 Alternative Names

CD97, TM7LN1 [Homo sapiens]

Cd97, AA409984, TM7LN1, EGF-TM7 receptor [Mus musculus]

CD97 Background

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. The CD97 is a receptor predominantly expressed in leukocytes and belongs to a new group of seven-span transmembrane molecules, which is also designed EGF-TM7 family. The family members are characterized by an extended extracellular region with several N-terminal epidermal growth factor-like domains two of which contain a calcium binding site. Muture CD 97 has two noncovalently associated subunits and is composed of a large extracellular protein (CD97 alpha) and a seven-membrane spanning protein (CD97 beta). CD97 is considered as a defining feature of G protein-coupled receptors. The effects that lymphocytes and erythrocytes adere to CD97-transfected COS cells suggest that CD97 has the ability to bind cellular ligands. CD97 alpha has three alternatively spliced isforms that are related to the calium binding EGF-like repeats in the microfibril protein fibrillin. Leukocytes strongly positive for CD97 are concentrated at sites of inflammation relative to CD97 expression in normal lymphoid tissues.

CD97 Related Studies

1. Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125–35.
2. Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
3. Gray JX, et al. (1996) CD97 is a processed, seven-transmembrane, heterodimeric receptor associated with inflammation. The journal of Immunology. 157 (12): 5438-47.
4. Hamann J,et al. (1998) Characterization of the CD55 (DAF)-binding site on the seven-span transmembrane receptor CD97.European Journal of Immunology. 28 (5): 1701–7.