CD96 Protein & Antibody

Cluster of Differentiation 96

CD96 Products

CD96 Protein, Recombinant

Molecule	Species	Description	Cat. No
CD96	Human	CD96 Protein, Recombinant	11202-H08H
CD96	Mouse	CD96 Protein, Recombinant	50758-M08H

CD96 Antibody

Molecule	Application	Description	Cat. No
Human CD96	WB,Elisa	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	11202-RP02

CD96 cDNA Clone

Molecule	Species	Description	Cat. No
CD96	Human	Homo sapiens CD96 cDNA Clone	HG11202-M
CD96	Mouse	CD96 cDNA Clone / ORF Clone	MG50758-G
CD96	Rat	CD96 cDNA Clone / ORF Clone	RG80338-G

CD96 Related Areas

Cancer>>Cancer Biomarkers>>CD96

Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>CD96

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>CD96

CD96 Alternative Names

CD96, DKFZp667E2122, MGC22596, TACTILE [Homo sapiens]

Cd96, 1700109I12Rik, Tactile [Mus musculus]

CD96 Background

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. The CD155 ligand CD96 is a member of the Ig superfamily. It's a immunoglobulin-like protein tentatively allocated to the repertoire of human NK receptors. NK cells recognize poliovirus receptor (PVR), a nectins and nectin-like protein family member serve to mediate cell-cell adhesion, cell migration, with the presence of an additional receptor, CD96. CD96 promotes NK cell adhesion to target cells expressing PVR, stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells. The effect the cells with mutated CD96 protein lost adhesion and growth activities indicates that CD96 mutations may cause a form of the C syndrome by interfering with cell adhesion and growth.

CD96 Related Studies

1. Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
2. Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125–35.
3. Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12
4. Anja Fuchs, et al. (2004) Cutting Edge: CD96 (Tactile) Promotes NK Cell-Target Cell Adhesion by Interacting with the Poliovirus Receptor (CD155). The Journal of Immunology.172 (7): 3994-8.
5. Seth S, et al.(2007) The murine pan T cell marker CD96 is an adhesion receptor for CD155 and nectin-1. Biochemical and Biophysical Research Communications. 364 (4): 959-65.