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Product Catalog
> CD95 Protein & Antibody (APO-1, Fas, TNFFSF6) CD95 Protein & Antibody (APO-1, Fas, TNFFSF6)
Cluster of Differentiation 95 (Accumulation of Photosystem One 1, Tumor Necrosis Factor Receptor Superfamily Member 6)
CD95 Products
CD95 Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No | Price / Size |
| CD95/APO-1/TNFRSF6 | Human | CD95 / APO-1 / TNFRSF6 Protein, Recombinant | 10217-H08H | $320 / 100µg |
| CD95/APO-1/TNFRSF6 | Mouse | CD95 / APO-1 / TNFRSF6 Protein, Recombinant | 50027-M08H | $290 / 100µg |
| CD95/APO-1/TNFRSF6 | Rat | FAS / TNFRSF6 / CD95 Protein | 80043-R02H | $290 / 100µg |
| CD95/APO-1/TNFRSF6 | Rat | CD95 / APO-1 / TNFRSF6 Protein, Recombinant | 80043-R08H | $300 / 100µg |
CD95 Antibody
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No | Price / Size |
| Human CD95/APO-1/TNFRSF6 |
WB, ELISA | CD95 / APO-1 / TNFRSF6 Antibody, Mouse MAb | 10217-MM04 | $200 / 100µg |
| Human CD95/APO-1/TNFRSF6 |
FCM | CD95 / APO-1 / TNFRSF6 / FAS Antibody ( FITC ) | 10217-MM10-F | $200 / 100 Tests |
| Human CD95/APO-1/TNFRSF6 |
FCM | CD95 / APO-1 / TNFRSF6 / FAS Antibody ( PE ) | 10217-MM10-P | $200 / 100 Tests |
| Human CD95/APO-1/TNFRSF6 |
WB, ELISA | CD95 / APO-1 / TNFRSF6 Antibody, Rabbit PAb | 10217-RP01 | $190 / 200µg |
| Human CD95/APO-1/TNFRSF6 |
WB, ELISA | CD95 / APO-1 / TNFRSF6 Antibody, Rabbit PAb (Antigen Affinity Purified) | 10217-RP02 | $290 / 100µg |
| Mouse CD95/APO-1/TNFRSF6 |
WB, ELISA | CD95 / APO-1 / TNFRSF6 Antibody, Rabbit PAb | 50027-RP01 | $190 / 200µg |
| Mouse CD95/APO-1/TNFRSF6 |
WB, ELISA | CD95 / APO-1 / TNFRSF6 Antibody, Rabbit PAb (Antigen Affinity Purified) | 50027-RP02 | $290 / 100µg |
| Mouse CD95/APO-1/TNFRSF6 |
ELISA | CD95 / APO-1 / TNFRSF6 / FAS Antibody | 50027-R006 | $290 / 100µg |
CD95 ELISA Kit
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No | Price / Size |
| Human CD95/APO-1/TNFRSF6 |
ELISA | CD95 / APO-1 / TNFRSF6 / FAS ELISA Pair Set, Human ELISA Pair Set | SEK10217 | $350 / 5 Plates |
CD95 cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No | Price / Size |
| CD95/APO-1/TNFRSF6 | Human | Homo sapiens CD95 / APO-1 / TNFRSF6 transcript variant 1 cDNA Clone(NM_000043.3) | HG10217-M | $95 |
| CD95/APO-1/TNFRSF6 | Mouse | Mus musculus CD95 / APO-1 / TNFRSF6 cDNA Clone | MG50027-U | $95 |
| CD95/APO-1/TNFRSF6 | Rat | Rattus norvegicus CD95 / APO-1 / TNFRSF6 cDNA Clone | RG80043-M | $95 |
| CD95/APO-1/TNFRSF6 | Cynomolgus | Cynomolgus monkey FAS Gene cDNA Clone / ORF Clone | CG90273-G | $95 |
CD95 Related Areas
Immunology>>Adaptive Immunity>>T Cell>>Regulatory T Cell>>CD95/APO-1/TNFRSF6
Immunology>>Cytokine & Receptor>>TNF Superfamily>>CD95/APO-1/TNFRSF6
Immunology>>Innate Immunity>>Natural Killer Cell (NK Cell)>>CD95/APO-1/TNFRSF6
Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD95/APO-1/TNFRSF6
Immunology>>Cluster of Differentiation>>Granulocyte CD Antigen>>Neutrophils>>CD95/APO-1/TNFRSF6
Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Other>>CD95/APO-1/TNFRSF6
Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells / Regulatory T Cells>>CD95/APO-1/TNFRSF6
CD95 Alternative Names
CD95, APO-1, FAS, TNFRSF6, APT1, FAS1, FASTM, ALPS1A
CD95 Background
CD95 (APO-1/Fas) is an important inducer of the extrinsic apoptosis signaling pathway and therapy induced apoptosis of many tumor cells has been linked to the activity of CD95. is a prototype death receptor characterized by the presence of an 80 amino acid death domain in its cytoplasmic tail. This domain is essential for the recruitment of a number of signaling components upon activation by either agonistic anti-CD95 antibodies or cognate CD95 ligand that initiate apoptosis. The complex of proteins that forms upon triggering of CD95 is called the death-inducting signaling complex (DISC). The DISC consists of an adaptor protein and initiator caspases and is essential for induction of apoptosis. CD95 is also crucial for the negative selection of B cells within the germinal center (GC). Impairment of CD95-mediated apoptosis results in defective affinity maturation and the persistence of autoreactive B-cell clones. Changes in the expression of CD95 and/or its ligand CD95L are frequently found in human cancer. The downregulation or mutation of CD95 has been proposed as a mechanism by which cancer cells avoid destruction by the immune system through reduced apoptosis sensitivity. Thus, CD95 has therefore been viewed as a tumor suppressor. CD95 has been reported to be involved in the activation of NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and the alternate pathways for CTL-mediated cytotoxicity. Accordingly, this protein is implicated in the pathogenesis of various malignancies and diseases of the immune system. The CD95/CD95L system was implicated in the etiology of inflammatory bowel disease (IBD) based, primarily, on the finding that CD95 is highly expressed in the intestinal epithelial cells and that epithelial apoptosis is increased in IBD.
CD95 Related Studies
- Müschen M, et al. (2002) The origin of CD95-gene mutations in B-cell lymphoma. Trends Immunol. 23(2): 75-80.
- Peter ME, et al. (2003) The CD95(APO-1/Fas) DISC and beyond. Cell Death Differ. 10(1): 26-35.
- Peter ME, et al. (2005) Does CD95 have tumor promoting activities Biochim Biophys Acta. 1755(1): 25-36.
- Chen L, et al. (2010) Cell death in the colonic epithelium during inflammatory bowel diseases: CD95/Fas and beyond. Inflamm Bowel Dis. 16(6): 1071-6.
CD95 related areas, pathways, and other information
TNF Superfamily Ligands
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TNF Receptor Superfamily
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