Anti-Fas Antibody (PE)

Cat: 10217-MM10-P
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Anti-Fas Antibody (PE) (Mouse Monoclonal antibody) General Information
Product name
Anti-Fas Antibody (PE)
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human Fas
Immunogen
Recombinant Human CD95 / APO-1 / TNFRSF6 / FAS protein (Catalog#10217-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD95 / APO-1 / TNFRSF6 / FAS (rh CD95 / APO-1 / TNFRSF6 / FAS; Catalog#10217-H08H; NP_000034.1; Met 1-Asn 173) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Source
Monoclonal Mouse IgG1 Clone #10
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
PE
Concentration
10 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Anti-Fas Antibody (PE) (Mouse Monoclonal antibody) Validated Applications

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Fas Antibody (PE) (Mouse Monoclonal antibody) Images
Human CD95/APO-1/TNFRSF6 Flow Cytometry (FC) 2585
Profile of anti-Human FAS (CD95) reactivity on Jurkat cells analyzed by flow cytometry.
Anti-Fas Antibody (PE) Alternative Names
Anti-ALPS1A Antibody;Anti-APO-1 Antibody;Anti-APT1 Antibody;Anti-CD95 Antibody;Anti-FAS1 Antibody;Anti-FASTM Antibody;Anti-TNFRSF6 Antibody
Fas Background Information

CD95 (APO-1/Fas) is an important inducer of the extrinsic apoptosis signaling pathway and therapy induced apoptosis of many tumor cells has been linked to the activity of CD95. is a prototype death receptor characterized by the presence of an 80 amino acid death domain in its cytoplasmic tail. This domain is essential for the recruitment of a number of signaling components upon activation by either agonistic anti-CD95 antibodies or cognate CD95 ligand that initiate apoptosis. The complex of proteins that forms upon triggering of CD95 is called the death-inducting signaling complex (DISC). The DISC consists of an adaptor protein and initiator caspases and is essential for induction of apoptosis. CD95 is also crucial for the negative selection of B cells within the germinal center (GC). Impairment of CD95-mediated apoptosis results in defective affinity maturation and the persistence of autoreactive B-cell clones. Changes in the expression of CD95 and/or its ligand CD95L are frequently found in human cancer. The downregulation or mutation of CD95 has been proposed as a mechanism by which cancer cells avoid destruction by the immune system through reduced apoptosis sensitivity. Thus, CD95 has therefore been viewed as a tumor suppressor. CD95 has been reported to be involved in the activation of NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and the alternate pathways for CTL-mediated cytotoxicity. Accordingly, this protein is implicated in the pathogenesis of various malignancies and diseases of the immune system. The CD95/CD95L system was implicated in the etiology of inflammatory bowel disease (IBD) based, primarily, on the finding that CD95 is highly expressed in the intestinal epithelial cells and that epithelial apoptosis is increased in IBD.

Full Name
Fas cell surface death receptor
Research Areas
References
  • Mschen M, et al. (2002) The origin of CD95-gene mutations in B-cell lymphoma. Trends Immunol. 23(2): 75-80.
  • Peter ME, et al. (2003) The CD95(APO-1/Fas) DISC and beyond. Cell Death Differ. 10(1): 26-35.
  • Peter ME, et al. (2005) Does CD95 have tumor promoting activities Biochim Biophys Acta. 1755(1): 25-36.
  • Chen L, et al. (2010) Cell death in the colonic epithelium during inflammatory bowel diseases: CD95/Fas and beyond. Inflamm Bowel Dis. 16(6): 1071-6.
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    Anti-Fas Antibody Rabbit Polyclonal ELISA 10217-RP01
    Anti-Fas Antibody (APC) Mouse Monoclonal FCM 10217-MM10-A
    Anti-Fas Antibody (FITC) Mouse Monoclonal FCM 10217-MM10-F
    Anti-Fas Antibody Mouse Monoclonal ELISA(Det) 10217-MM16
    Anti-Fas Antibody Rabbit Polyclonal ELISA 10217-RP02
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