Anti-Fas Antibody

Cat: 50027-RP02
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Anti-Fas Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Fas Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse Fas
Immunogen
Recombinant Mouse CD95 protein (Catalog#50027-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse CD95 (rM CD95; Catalog#50027-M08H; NP_032013.2; Met 1-Arg 169). CD95 specific IgG was purified by mouse CD95 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Fas Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Fas Antibody Alternative Names
Anti-AI196731 Antibody;Anti-APO1 Antibody;Anti-APT1 Antibody;Anti-CD95 Antibody;Anti-lpr Antibody;Anti-TNFR6 Antibody;Anti-Tnfrsf6 Antibody
Fas Background Information

CD95 (APO-1/Fas) is an important inducer of the extrinsic apoptosis signaling pathway and therapy induced apoptosis of many tumor cells has been linked to the activity of CD95. is a prototype death receptor characterized by the presence of an 80 amino acid death domain in its cytoplasmic tail. This domain is essential for the recruitment of a number of signaling components upon activation by either agonistic anti-CD95 antibodies or cognate CD95 ligand that initiate apoptosis. The complex of proteins that forms upon triggering of CD95 is called the death-inducting signaling complex (DISC). The DISC consists of an adaptor protein and initiator caspases and is essential for induction of apoptosis. CD95 is also crucial for the negative selection of B cells within the germinal center (GC). Impairment of CD95-mediated apoptosis results in defective affinity maturation and the persistence of autoreactive B-cell clones. Changes in the expression of CD95 and/or its ligand CD95L are frequently found in human cancer. The downregulation or mutation of CD95 has been proposed as a mechanism by which cancer cells avoid destruction by the immune system through reduced apoptosis sensitivity. Thus, CD95 has therefore been viewed as a tumor suppressor. CD95 has been reported to be involved in the activation of NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and the alternate pathways for CTL-mediated cytotoxicity. Accordingly, this protein is implicated in the pathogenesis of various malignancies and diseases of the immune system. The CD95/CD95L system was implicated in the etiology of inflammatory bowel disease (IBD) based, primarily, on the finding that CD95 is highly expressed in the intestinal epithelial cells and that epithelial apoptosis is increased in IBD.

Full Name
Fas cell surface death receptor
Research Areas
References
  • Mschen M, et al. (2002) The origin of CD95-gene mutations in B-cell lymphoma. Trends Immunol. 23(2): 75-80.
  • Peter ME, et al. (2003) The CD95(APO-1/Fas) DISC and beyond. Cell Death Differ. 10(1): 26-35.
  • Peter ME, et al. (2005) Does CD95 have tumor promoting activities Biochim Biophys Acta. 1755(1): 25-36.
  • Chen L, et al. (2010) Cell death in the colonic epithelium during inflammatory bowel diseases: CD95/Fas and beyond. Inflamm Bowel Dis. 16(6): 1071-6.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Fas Antibody Rabbit Polyclonal ELISA 80043-T16
    Anti-Fas Antibody Rabbit Polyclonal ELISA 80043-RP01
    Anti-Fas Antibody Rabbit Monoclonal ELISA 80043-R018
    Anti-Fas Antibody Rabbit Monoclonal FCM 80043-R028
    Anti-Fas Antibody Rabbit Monoclonal ELISA 80043-R105
    Anti-Fas Antibody (PE) Rabbit Monoclonal FCM 80043-R028-P
    Anti-Fas Antibody Rabbit Polyclonal ELISA 50027-RP01
    Anti-Fas Antibody (PE) Rabbit Monoclonal FCM 50027-R004-P
    Anti-Fas Antibody Rabbit Monoclonal FCM,ICC/IF,IF 50027-R004
    Anti-Fas Antibody (FITC) Rabbit Monoclonal FCM 50027-R004-F
    Anti-Fas Antibody (APC) Rabbit Monoclonal FCM 50027-R004-A
    Anti-Fas Antibody Rabbit Monoclonal ELISA 50027-R006
    Anti-Fas Antibody Rabbit Polyclonal ELISA 10217-T16
    Anti-Fas Antibody Mouse Monoclonal ELISA 10217-MM04
    Anti-Fas Antibody Mouse Monoclonal FCM 10217-MM10
    Anti-Fas Antibody Rabbit Monoclonal ELISA 10217-R225
    Anti-Fas Antibody Mouse Monoclonal ELISA(Cap) 10217-MM12
    Anti-Fas Antibody (PE) Mouse Monoclonal FCM 10217-MM10-P
    Anti-Fas Antibody Rabbit Polyclonal ELISA 10217-RP01
    Anti-Fas Antibody (APC) Mouse Monoclonal FCM 10217-MM10-A
    Anti-Fas Antibody (FITC) Mouse Monoclonal FCM 10217-MM10-F
    Anti-Fas Antibody Mouse Monoclonal ELISA(Det) 10217-MM16
    Anti-Fas Antibody Rabbit Polyclonal ELISA 10217-RP02
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