CD93 / C1qR Protein

Cluster of Differentiation 93 / Complement component C1q receptor

CD93 / C1qR Products

CD93 / C1qR Protein, Recombinant

Molecule	Species	Description	Cat. No
CD93/C1qR	Human	CD93/C1qR Protein, Recombinant	12589-H02H
CD93/C1qR	Human	CD93/C1qR Protein, Recombinant	12589-H08H

CD93 / C1qR cDNA Clone

Molecule	Species	Description	Cat. No
CD93/C1qR	Human	Mouse CD93/C1qR cDNA Clone / ORF Clone	MG50759-G
CD93/C1qR	Rat	Rat CD93/C1qR cDNA Clone / ORF Clone	RG80207-G

CD93 / C1qR Related Areas

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hematopoietic Stem Cell Marker>>CD93/C1qR

Immunology>>Cluster of Differentiation>>Hematopoietic Stem Cell CD Marker>>CD93/C1qR

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers>>CD93/C1qR

Immunology>>Adhesion Molecule>>Lectin>>CD93/C1qR

CD93 / C1qR Alternative Names

CD93, C1qR, C1QR1, C1qR(P), C1qRP, CDw93, ECSM3, MXRA4, dJ737E23.1 [Homo sapiens]

Cd93, C1qR, C1qr1, RP23-70N3.4, 6030404G09Rik, AA145088, AA4.1, AW555904, C1qrp, Ly68 [Mus musculus]

CD93 / C1qR Background

CD93 or C1q receptor 1 (C1qR) is an about 120 kDa O-sialoglycoprotein that within the hematopoietic system is selectively expressed on cells of the myeloid lineage. CD93/C1qR is a highly glycosylated transmembrane protein expressed on monocytes, neutrophils, endothelial cells, and stem cells. CD93 was originally identified as a myeloid cell-surface marker and subsequently associated with an ability to modulate phagocytosis of suboptimally opsonized immunoglobulin G and complement particles in vitro. CD93/C1qR, a receptor expressed during early B-cell development, is reinduced during plasma-cell differentiation. High CD93/CD138 expression was restricted to antibody-secreting cells both in T-dependent and T-independent responses as naive, memory, and germinal-center B cells remained CD93-negative. CD93 was expressed on (pre)plasmablasts/plasma cells, including long-lived plasma cells that showed decreased cell cycle activity, high levels of isotype-switched Ig secretion, and modification of the transcriptional network. CD93 is important for the maintenance of plasma cells in bone marrow niches.

CD93 / C1qR Related Studies

1. Bohlson SS, et al. (2005) CD93 is rapidly shed from the surface of human myeloid cells and the soluble form is detected in human plasma. J Immunol. 175(2): 1239-47.
2. Norsworthy PJ, et al. (2004) Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosis. J Immunol. 172(6): 3406-14.
3. Chevrier S, et al. (2009) CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche. Proc Natl Acad Sci U S A. 106(10): 3895-900.