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CD8a Antibody (FITC), Rabbit MAb

  • Human CEACAM‑1/CD66a Flow Cytometry (FC) 5367
  • CD8a Antibody (FITC), Rabbit MAb, Flow cytometric
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Mouse CD8A Antibody Product Information
Immunogen:Recombinant Mouse CD8a protein (Catalog#50389-M08H)
Clone ID:208
Ig Type:Rabbit IgG
Concentration:2 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD8a (rM CD8a; Catalog#50389-M08H; NP_001074579.1; Met 1-Tyr 196) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Mouse CD8A Antibody FC Application Image
CD8a Antibody (FITC), Rabbit MAb, Flow cytometric
[Click to enlarge image]
Caption:
Flow cytometric analysis of CD8a expression on spleen lymphocytes. BALB/c splenocytes were stained with FITC-conjugated anti-Mouse CD8a (50389-R208-F). The histogram were derived from the gated events based on light scattering characteristics of lymphocytes.
Other CD8A Antibody Products
CD8/CD8 alpha/Leu-2 Background

T-cell surface glycoprotein CD8 alpha chain, also known as CD8a, is a single-pass type I  membrane protein. The CD8 glycoprotein is expressed by thymocytes, mature T cells and natural killer (NK) cells and has been implicated in the recognition of monomorphic determinants on major histocompatibility complex (MHC) Class I antigens, and in signal transduction during the course of T-cell activation. Both human and rodent CD8 antigens are comprised of two distinct polypeptide chains, alpha and beta. The Ig domains of CD8 alpha are involved in controlling the ability of CD8 to be expressed. Mutation of B- and F-strand cysteine residues in CD8 alpha reduced the ability of the protein to fold properly and, therefore, to be expressed. Defects in CD8A are a cause of familial CD8 deficiency. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.

Mouse CD8/CD8 alpha/Leu-2 References
References Devine, L. et al., 2000, J Immunol. 164 (2): 833-8. Arcaro, A. et al., 2000, J Immunol. 165 (4): 2068-76. Saha, K. et al., 2001, Nat Med. 7 (1): 65-72. Romero, P. et al., 2005, Eur J Immunol. 35 (11): 3092-4.
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Catalog: 50389-R208-F-25
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25 Test
100 Tests
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Datasheet & Documentation

All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"