All CD8 beta reagents are produced in house and quality controlled, including 4 CD8 beta Antibody, 40 CD8 beta Gene, 3 CD8 beta Lysate, 3 CD8 beta Protein, 2 CD8 beta qPCR. All CD8 beta reagents are ready to use.
Recombinant CD8 beta proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc, C-cleavage.
CD8 betaantibodies are validated with different applications, which are IHC-P, ELISA.
CD8 betacDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each CD8 beta of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
CD8B (CD8b molecule), also known as P37 and LEU2, contains 1 Ig-like V-type (immunoglobulin-like) domain. The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. P37 gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. CD8 is thought to play a role in the process of T-cell mediated killing.