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CD89 / FCAR Antibody, Rabbit PAb, Antigen Affinity Purified

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    Rat CD89/FCAR Antibody Product Information
    Immunogen:Recombinant Rat CD89 / FCAR protein (Catalog#80014-R08H)
    Clone ID:
    Ig Type:Rabbit IgG
    Concentration:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:Produced in rabbits immunized with purified, recombinant Rat CD89 / FCAR (rR CD89 / FCAR; Catalog#80014-R08H; NP_973721.1; Met 1-Asn 228). CD89 / FCAR specific IgG was purified by Rat CD89 / FCAR affinity chromatography.
    Other CD89/FCAR Antibody Products
    Reactivity: Human  
    Application: FCM  
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    10414-MM02-A-50
    10414-MM02-A-100
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    Reactivity: Human  
    Application: ELISA  
      10414-RP01-400
      10414-RP01-100
      10414-RP01-200
       
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      Reactivity: Human  
      Application: ELISA  
        10414-RP02-200
        10414-RP02-50
        10414-RP02-100
        200 µg 
        50 µg 
        100 µg 
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        Reactivity: Human  
        Application: ELISA  FCM  
        • Slide 1
        10414-MM02-100
        10414-MM02-200
        10414-MM02-50
        100 µg 
        200 µg 
        50 µg 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  
          10414-R006-50
          10414-R006-100
          50 µg 
          100 µg 
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          Reactivity: Human  
          Application: FCM  
          • Slide 1
          10414-MM02-P-50
          10414-MM02-P-100
          50 Tests 
          100 Tests 
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          Reactivity: Human  
          Application: FCM  
          • Slide 1
          10414-MM02-F-50
          10414-MM02-F-100
          50 Tests 
          100 Tests 
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          Reactivity: Rat  
          Application: ELISA  
            80014-R013-100
            80014-R013-50
            100 µg 
            50 µg 
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            Reactivity: Rat  
            Application: ELISA  
              80014-RP01-400
              80014-RP01-100
              80014-RP01-200
               
              100 µg 
              200 µg 
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              CD89/FCAR Background

              FCAR, also called FcαRI or CD89, is a type I  transmembrane receptor for Fc region of IgA which is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum. This receptor is present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, especially phagocytes located in mucosal areas. Upon ligand IgA binding, FcαRI associates with the FcR γ signaling molecule bearing the immunoreceptor tyrosine-based activation motif (ITAM) through a unique charge-based mechanism and triggers multiple cell-mediated immune responses. It has been reported that Fc RI is a dual-function receptor that can mediate both inflammatory and anti-inflammatory responses depending on the type of interaction with its ligand. Sustained aggregation of FCAR results in activation of target-cell functions such as antigen presentation and cytokine release. In contrast, Monomeric targeting with serum IgA or with a variety of anti-FcαRI Fab fragments triggers an inhibitory response and additionally induces apoptosis. FcαRI thus play an fundamental role in preventing tumor development and growth, as well as in controlling inflammation.

              Rat CD89/FCAR References
              1. Maliszewski, C.R. et al., 1990, J. Exp. Med. 172: 1665-1672.
              2. Launay, P. et al., 1999, J. Biol. Chem. 274: 7216-7225.
              3. Monteiro, R.C. et al., 2003, Annu. Rev. Immunol. 21: 177-204.
              4. Otten, M.A. et al., 2005, J. Immunol. 174: 5472-5480.
              5. Pasquier, B. et al., 2005, Immunity. 22:31-42.
              6. Kanamaru, Y. et al., 2007, Blood. 109: 203-211.
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              Size / Price
              Catalog: 80014-RP02-200
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              Datasheet & Documentation

              All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
              Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"