Anti-CD89 Antibody

Cat: 10414-MM02
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All CD89 Reagents
Anti-CD89 Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-CD89 Antibody
Validated applications
ELISA,FCM
Species reactivity
Reacts with: Human
Specificity
Human CD89
Immunogen
Recombinant Human CD89 protein (Catalog#10414-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD89 / FCAR (rh CD89; Catalog#10414-H08H; NP_001991.1; Met 1-Asn 227). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #6G3G3E7
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CD89 Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  
FCM 1:25-1:100  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD89 Antibody (Mouse Monoclonal antibody) Images
Human CD89/FCAR Flow Cytometry (FC) 5228
Flow cytometric analysis of Human CD89 expression on Human blood granulocytes. Cells were stained with purified anti-Human CD89, then a FITC-conjugated second step antibody. The histogram were derived from gated events with the forward and side light-scatter characteristics of viable granuolcytes.
Anti-CD89 Antibody Alternative Names
Anti-CD89 Antibody;Anti-CTB-61M7.2 Antibody;Anti-FcalphaRI Antibody;Anti-FCAR Antibody;Anti-XXbac-BPG230H20.5 Antibody
CD89 Background Information

FCAR, also called FcαRI or CD89, is a type I  transmembrane receptor for Fc region of IgA which is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum. This receptor is present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, especially phagocytes located in mucosal areas. Upon ligand IgA binding, FcαRI associates with the FcR γ signaling molecule bearing the immunoreceptor tyrosine-based activation motif (ITAM) through a unique charge-based mechanism and triggers multiple cell-mediated immune responses. It has been reported that Fc RI is a dual-function receptor that can mediate both inflammatory and anti-inflammatory responses depending on the type of interaction with its ligand. Sustained aggregation of FCAR results in activation of target-cell functions such as antigen presentation and cytokine release. In contrast, Monomeric targeting with serum IgA or with a variety of anti-FcαRI Fab fragments triggers an inhibitory response and additionally induces apoptosis. FcαRI thus play an fundamental role in preventing tumor development and growth, as well as in controlling inflammation.

Full Name
Fc fragment of IgA receptor
References
  • Maliszewski, C.R. et al., 1990, J. Exp. Med. 172: 1665-1672.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CD89 Antibody Rabbit Monoclonal ELISA 80014-R013
    Anti-CD89 Antibody Rabbit Polyclonal ELISA 80014-T16
    Anti-CD89 Antibody Rabbit Polyclonal ELISA 80014-RP01
    Anti-CD89 Antibody Rabbit Polyclonal ELISA 80014-RP02
    Anti-CD89 Antibody Rabbit Polyclonal ELISA 10414-RP02
    Anti-CD89 Antibody (APC) Mouse Monoclonal FCM 10414-MM02-A
    Anti-CD89 Antibody Rabbit Monoclonal ELISA 10414-R006
    Anti-CD89 Antibody Rabbit Polyclonal ELISA 10414-RP01
    Anti-CD89 Antibody (FITC) Mouse Monoclonal FCM 10414-MM02-F
    Anti-CD89 Antibody (PE) Mouse Monoclonal FCM 10414-MM02-P
    Anti-CD89 Antibody Rabbit Monoclonal ELISA(Cap) 10414-R002
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