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CD89 / FCAR Antibody, Rabbit PAb, Antigen Affinity Purified

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    Human CD89/FCAR Antibody Product Information
    Immunogen:Recombinant Human CD89 protein (Catalog#10414-H08H)
    Clone ID:
    Ig Type:Rabbit IgG
    Concentration:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:Produced in rabbits immunized with purified, recombinant Human CD89 / FCAR (rh CD89; Catalog#10414-H08H; NP_001991.1; Met 1-Asn 227). CD89 specific IgG was purified by human CD89 affinity chromatography.
    Other CD89/FCAR Antibody Products
    Reactivity: Human  
    Application: FCM  
    • Slide 1
    10414-MM02-A-50
    10414-MM02-A-100
    50 Tests 
    100 Tests 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      10414-RP01-400
      10414-RP01-100
      10414-RP01-200
       
      100 µg 
      200 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  FCM  
      • Slide 1
      10414-MM02-100
      10414-MM02-200
      10414-MM02-50
      100 µg 
      200 µg 
      50 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10414-R006-50
        10414-R006-100
        50 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: FCM  
        • Slide 1
        10414-MM02-P-50
        10414-MM02-P-100
        50 Tests 
        100 Tests 
        Add to Cart
        Reactivity: Human  
        Application: FCM  
        • Slide 1
        10414-MM02-F-50
        10414-MM02-F-100
        50 Tests 
        100 Tests 
        Add to Cart
        Reactivity: Rat  
        Application: ELISA  
          80014-R013-100
          80014-R013-50
          100 µg 
          50 µg 
          Add to Cart
          Reactivity: Rat  
          Application: ELISA  
            80014-RP01-400
            80014-RP01-100
            80014-RP01-200
             
            100 µg 
            200 µg 
            Add to Cart
            Reactivity: Rat  
            Application: ELISA  
              80014-RP02-200
              80014-RP02-50
              80014-RP02-100
              200 µg 
              50 µg 
              100 µg 
              Add to Cart
              CD89/FCAR Background

              FCAR, also called FcαRI or CD89, is a type I  transmembrane receptor for Fc region of IgA which is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum. This receptor is present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, especially phagocytes located in mucosal areas. Upon ligand IgA binding, FcαRI associates with the FcR γ signaling molecule bearing the immunoreceptor tyrosine-based activation motif (ITAM) through a unique charge-based mechanism and triggers multiple cell-mediated immune responses. It has been reported that Fc RI is a dual-function receptor that can mediate both inflammatory and anti-inflammatory responses depending on the type of interaction with its ligand. Sustained aggregation of FCAR results in activation of target-cell functions such as antigen presentation and cytokine release. In contrast, Monomeric targeting with serum IgA or with a variety of anti-FcαRI Fab fragments triggers an inhibitory response and additionally induces apoptosis. FcαRI thus play an fundamental role in preventing tumor development and growth, as well as in controlling inflammation.

              Human CD89/FCAR References
              1. Maliszewski, C.R. et al., 1990, J. Exp. Med. 172: 1665-1672.
              2. Launay, P. et al., 1999, J. Biol. Chem. 274: 7216-7225.
              3. Monteiro, R.C. et al., 2003, Annu. Rev. Immunol. 21: 177-204.
              4. Otten, M.A. et al., 2005, J. Immunol. 174: 5472-5480.
              5. Pasquier, B. et al., 2005, Immunity. 22:31-42.
              6. Kanamaru, Y. et al., 2007, Blood. 109: 203-211.
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              Size / Price
              Catalog: 10414-RP02-200
              List Price: 
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              Datasheet & Documentation

              All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
              Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"