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CD89 / FCAR Antibody, Rabbit PAb, Antigen Affinity Purified

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Human CD89/FCAR Antibody Product Information
Immunogen:Recombinant Human CD89 protein (Catalog#10414-H08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Human CD89 / FCAR (rh CD89; Catalog#10414-H08H; NP_001991.1; Met 1-Asn 227). CD89 specific IgG was purified by human CD89 affinity chromatography.
Human CD89/FCAR Antibody Usage Guide
Specificity:Human CD89 / FCAR
Application:ELISA

ELISA: 0.5-1.0 μg/mL

This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Human CD89. The detection limit for Human CD89 is 0.00245 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other CD89/FCAR Antibody Products
Reactivity: Human  
Application: FCM  
  • Slide 1
10414-MM02-A-50
10414-MM02-A-100
50 Tests 
100 Tests 
Add to Cart
Reactivity: Human  
Application: ELISA  
    10414-RP01-400
    10414-RP01-100
    10414-RP01-200
     
    100 µg 
    200 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  FCM  
    • Slide 1
    10414-MM02-100
    10414-MM02-200
    10414-MM02-50
    100 µg 
    200 µg 
    50 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      10414-R006-50
      10414-R006-100
      50 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: FCM  
      • Slide 1
      10414-MM02-P-50
      10414-MM02-P-100
      50 Tests 
      100 Tests 
      Add to Cart
      Reactivity: Human  
      Application: FCM  
      • Slide 1
      10414-MM02-F-50
      10414-MM02-F-100
      50 Tests 
      100 Tests 
      Add to Cart
      Reactivity: Rat  
      Application: ELISA  
        80014-R013-100
        80014-R013-50
        100 µg 
        50 µg 
        Add to Cart
        Reactivity: Rat  
        Application: ELISA  
          80014-RP01-400
          80014-RP01-100
          80014-RP01-200
           
          100 µg 
          200 µg 
          Add to Cart
          Reactivity: Rat  
          Application: ELISA  
            80014-RP02-200
            80014-RP02-50
            80014-RP02-100
            200 µg 
            50 µg 
            100 µg 
            Add to Cart
            CD89/FCAR Background

            FCAR, also called FcαRI or CD89, is a type I  transmembrane receptor for Fc region of IgA which is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum. This receptor is present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, especially phagocytes located in mucosal areas. Upon ligand IgA binding, FcαRI associates with the FcR γ signaling molecule bearing the immunoreceptor tyrosine-based activation motif (ITAM) through a unique charge-based mechanism and triggers multiple cell-mediated immune responses. It has been reported that Fc RI is a dual-function receptor that can mediate both inflammatory and anti-inflammatory responses depending on the type of interaction with its ligand. Sustained aggregation of FCAR results in activation of target-cell functions such as antigen presentation and cytokine release. In contrast, Monomeric targeting with serum IgA or with a variety of anti-FcαRI Fab fragments triggers an inhibitory response and additionally induces apoptosis. FcαRI thus play an fundamental role in preventing tumor development and growth, as well as in controlling inflammation.

            Human CD89/FCAR References
            1. Maliszewski, C.R. et al., 1990, J. Exp. Med. 172: 1665-1672.
            2. Launay, P. et al., 1999, J. Biol. Chem. 274: 7216-7225.
            3. Monteiro, R.C. et al., 2003, Annu. Rev. Immunol. 21: 177-204.
            4. Otten, M.A. et al., 2005, J. Immunol. 174: 5472-5480.
            5. Pasquier, B. et al., 2005, Immunity. 22:31-42.
            6. Kanamaru, Y. et al., 2007, Blood. 109: 203-211.
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            All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
            Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"