CD86 Protein & Antibody (B7-2)

Cluster of Differentiation 86 (B-lymphocyte activation antigen B7-2)

CD86 Products

CD86 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CD86/B7-2	Human	CD86/ B7-2/Fc Protein, Recombinan	10699-H03H
CD86/B7-2	Human	CD86/B7-2 Protein, Recombinant	10699-H08H
CD86/B7-2	Mouse	CD86/B7-2/Fc Protein, Recombinant	50068-M03H
CD86/B7-2	Mouse	CD86/B7-2 Protein, Recombinant	50068-M08H
CD86/B7-2	Rat	CD86/B7-2 Protein, Recombinant	80025-R08H

10699-H03H: Measured by its ability to bind human CD28 in a functional Elisa.

10699-H08H: Immobilized human CD86 at 20 µg/ml (100 µl/well) can bind human CD28 with a linear ranger of 32-800 ng/ml. Measured by its binding ability in a functional ELISA.

50068-M03H: Immobilized human CD28 at 20 µg/ml (100 µl/well) can bind mouse CD86 Fc Chimera with a linear ranger of 6.4-160 ng/ml. Measured by its binding ability in a functional ELISA.

50068-M08H: Immobilized mouse CD86 at 20 µg/ml (100 µl/well) can bind mouse CD28 with a linear ranger of 6.4-800 ng/ml. Measured by its binding ability in a functional ELISA.

80025-R08H: Immobilized rat CD86 at 2 µg/ml (100 µl/well) can bind mouse CD28 with a linear ranger of 6.4-160 ng/ml. Measured by its binding ability in a functional ELISA.

CD86 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human CD86/B7-2	WB, ELISA	Mouse Monoclonal Antibody	10699-MM02
Human CD86/B7-2	FCM	CD86 / B7-2 Antibody ( FITC )	10699-MM06-F
Human CD86/B7-2	WB, ELISA	Rabbit Monoclonal Antibody	10699-R118
Human CD86/B7-2	WB, ELISA	Rabbit Polyclonal Antibody	10699-RP01
Human CD86/B7-2	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10699-RP02
Mouse CD86/B7-2	WB, ELISA	CD86/B7-2 Antibody, Rabbit Mab	50068-R003
Mouse CD86/B7-2	WB, ELISA	Rabbit Polyclonal Antibody	50068-RP01
Mouse CD86/B7-2	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	50068-RP02
Rat CD86/B7-2	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	80025-RP02
Rat CD86/B7-2	WB, ELISA	CD86 / B7-2 Antibody	80025-MM04

CD86 ELISA Kits

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human CD86/B7-2	ELISA	CD86 / B7-2 ELISA Pair Set, Human ELISA Pair Set	SEK10699
Rat CD86/B7-2	ELISA	D86 / B7-2 ELISA Pair Set, Rat ELISA Pair Set	SEK80025

CD86 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CD86/B7-2	Human	Homo sapiens CD86/B7-2 cDNA Clone(NM_006889.3)	HG10699-M
CD86/B7-2	Mouse	Mus musculus CD86/B7-2 cDNA Clone	MG50068-M
CD86/B7-2	Rat	Rattus norvegicus CD86/B7-2 cDNA Clone	RG80025-M
CD86/B7-2	Cynomolgus	Cynomolgus monkey CD86 Gene cDNA Clone / ORF Clone	CG90270-G

CD86 Related Areas

Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>CD86/B7-2

Immunology>>Adaptive Immunity>>T Cell>>Regulatory T Cell / T Cell Antigen Recognition>>CD86/B7-2

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD86/B7-2

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Other>>CD86/B7-2

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Regulatory T Cells / T Cell Antigen Recognition>>CD86/B7-2

CD86 Alternative Names

CD86, B7-2, B70, CD28LG2, LAB72, MGC34413 [Homo sapiens]

CD86, B7-2, B70, B7, B7.2, CLS1, Cd28l2, ETC-1, Ly-58, Ly58, MB7, MB7-2, TS/A-2 [Mus musculus]

CD86 Background

CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominantly as a monomer on cell surfaces and interacts with two co-stimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus induces the signal pathways which regulate T cell activation and tolerance, cytokine production, and the generation of CTL. It is indicated that contacts between B and T helper cells mediated by CD86 encourage signals for the proliferation and IgG secretion of normal B cells and B cell lymphomas. Recent study has revealed that CD86 also promotes the generation of a mature APC repertoire and promotes APC function and survival. CD86 has an important role in chronic hemodialysis, allergic pulmonary inflammation, arthritis, and antiviral responses, and thus is regarded as a promising candidate for immune therapy.

CD86 Related Studies

Chen YQ, et al. (2006) CD28/CTLA-4--CD80/CD86 and ICOS--B7RP-1 costimulatory pathway in bronchial asthma. Allergy. 61(1): 15-26.
Rau FC, et al. (2009) B7-1/2 (CD80/CD86) direct signaling to B cells enhances IgG secretion. J Immunol. 183(12): 7661-71.
Dai ZS, et al. (2009) Defective expression and modulation of B7-2/CD86 on B cells in B cell chronic lymphocytic leukemia. Int J Hematol. 89(5): 656-63.

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