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CD86 / ETC-1 / B7-2 Antibody, Rabbit PAb

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    Mouse B7-2/CD86 Antibody Product Information
    Immunogen:Recombinant Mouse CD86 protein (Catalog#50068-M08H)
    Clone ID:
    Ig Type:Rabbit IgG
    Concentration:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:Produced in rabbits immunized with purified, recombinant Mouse CD86 extracellular domain (rM CD86; Catalog#50068-M08H; NP_062261.3; Met 1-Glu 245). Total IgG was purified by Protein A affinity chromatography.
    Other B7-2/CD86 Antibody Products
    Reactivity: Human  
    Application: ELISA  
      10699-RP01-100
      10699-RP01-200
      10699-RP01-400
      100 µg 
      200 µg 
       
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10699-RP02-50
        10699-RP02-100
        10699-RP02-200
        50 µg 
        100 µg 
        200 µg 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  
          10699-MM02-50
          10699-MM02-100
          10699-MM02-200
          50 µg 
          100 µg 
          200 µg 
          Add to Cart
          Reactivity: Human  
          Application: ELISA  
            10699-R118-50
            10699-R118-100
            50 µg 
            100 µg 
            Add to Cart
            Reactivity: Human  
            Application: FCM  
            • Slide 1
            10699-MM06-F-50
            10699-MM06-F-100
            50 Tests 
            100 Tests 
            Add to Cart
            Reactivity: Human  
            Application: FCM  
            • Slide 1
            10699-MM06-P-50
            10699-MM06-P-100
            50 Tests 
            100 Tests 
            Add to Cart
            Reactivity: Human  
            Application: FCM  
            • Slide 1
            10699-MM06-200
            10699-MM06-100
            10699-MM06-50
            200 µg 
            100 µg 
            50 µg 
            Add to Cart
            Reactivity: Human  
            Application: FCM  
            • Slide 1
            10699-MM06-A-100
            10699-MM06-A-50
            100 Tests 
            50 Tests 
            Add to Cart
            Reactivity: Mouse  
            Application: ELISA  WB  IP  
            • Slide 1
            • Slide 1
            50068-RP02-50
            50068-RP02-100
            50068-RP02-200
            50 µg 
            100 µg 
            200 µg 
            Add to Cart
            Reactivity: Mouse  
            Application: ELISA  
              50068-R003-50
              50068-R003-100
              50 µg 
              100 µg 
              Add to Cart
              Reactivity: Rat  
              Application: ELISA  
                80025-RP02-50
                80025-RP02-100
                80025-RP02-200
                50 µg 
                100 µg 
                200 µg 
                Add to Cart
                Reactivity: Rat  
                Application: ELISA  
                  80025-MM04-50
                  80025-MM04-100
                  80025-MM04-200
                  50 µg 
                  100 µg 
                  200 µg 
                  Add to Cart
                  Reactivity: Rat  
                  Application: ELISA  
                    80025-RP01-200
                    80025-RP01-100
                    80025-RP01-400
                    200 µg 
                    100 µg 
                     
                    Add to Cart
                    Reactivity: Cynomolgus  
                    Application: ELISA  
                      90270-R021-100
                      90270-R021-50
                      100 µg 
                      50 µg 
                      Add to Cart
                      CD86/B7-2 Background

                      CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominantly as a monomer on cell surfaces and interacts with two co-stimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus induces the signal pathways which regulate T cell activation and tolerance, cytokine production, and the generation of CTL. It is indicated that contacts between B and T helper cells mediated by CD86 encourage signals for the proliferation and IgG secretion of normal B cells and B cell lymphomas. Recent study has revealed that CD86 also promotes the generation of a mature APC repertoire and promotes APC function and survival. CD86 has an important role in chronic hemodialysis, allergic pulmonary inflammation, arthritis, and antiviral responses, and thus is regarded as a promising candidate for immune therapy.

                      Immune Checkpoint
                      Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: IP Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
                      Immune Checkpoint Proteins
                      Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

                      Immunotherapy   Cancer Immunotherapy   Targeted Therapy

                      Mouse CD86/B7-2 References
                    • Chen YQ, et al. (2006) CD28/CTLA-4--CD80/CD86 and ICOS--B7RP-1 costimulatory pathway in bronchial asthma. Allergy. 61(1): 15-26.
                    • Rau FC, et al. (2009) B7-1/2 (CD80/CD86) direct signaling to B cells enhances IgG secretion. J Immunol. 183(12): 7661-71.
                    • Dai ZS, et al. (2009) Defective expression and modulation of B7-2/CD86 on B cells in B cell chronic lymphocytic leukemia. Int J Hematol. 89(5): 656-63.
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                      Size / Price
                      Catalog: 50068-RP01-100
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                      Datasheet & Documentation

                      All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
                      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"