All CD84 reagents are produced in house and quality controlled, including 8 CD84 Antibody, 1 CD84 ELISA, 36 CD84 Gene, 1 CD84 IPKit, 4 CD84 Lysate, 4 CD84 Protein, 2 CD84 qPCR. All CD84 reagents are ready to use.
Recombinant CD84 proteins are expressed by HEK293 Cells with fusion tags as C-His, C-human IgG1-Fc.
CD84antibodies are validated with different applications, which are ELISA, ELISA(Cap), ELISA(Det), WB, IP.
CD84cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each CD84 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
CD84ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
The CD2 family receptors are type I transmembrane glycoproteins belonging to immunoglobulin (Ig) superfamily characterized by a membrane-proximal Ig constant 2 (C2) domain and a membrane-distal variable (V) domain that is responsible for ligand recognition. CD84, also known as LY9B and SLAMF5, is a homophilic member of the SLAM (signaling lymphocyte activation molecule) subfamily of the CD2 family. The SLAM family receptorsmediate signal transduction through the interaction of its ITSM (immunoreceptor tyrosine-based switch motifs) in the intracellular region and the SH2 domain of adaptor molecules SAP (SLAM-associated protein) and EAT-2 (EWS-activated transcript 2), and accordingly modulate both adaptive and innate immune responses. The CD84-CD84 interaction was independent of its cytoplasmic tail. Thus, CD84 is its own ligand and acts as a costimulatory molecule. CD84 is expressed on cells from almost all hematopoietic lineages and on CD34+ hematopoietic progenitor cells, suggesting that CD84 serves as a marker for committed hematopoietic progenitor cells.