Anti-CD84 Antibody

Cat: 10100-R006
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All CD84 Reagents
Anti-CD84 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-CD84 Antibody
Validated applications
Species reactivity
Reacts with: Human
Human CD84
Recombinant Human CD84 protein (Catalog#10100-H08H)
This antibody was obtained from a rabbit immunized with purified, recombinant Human CD84 extracellular domain (rh CD84; Catalog#10100-H08H; Met 1-Gly 225; NP_003865.1).
Monoclonal Rabbit IgG Clone #6
Protein A
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CD84 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:1000  
ELISA 1:25000-1:50000  
IP 0.2-1 μL/mg of lysate  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD84 Antibody (Rabbit Monoclonal antibody) Images
Human CD84 Immunoprecipitation(IP) 6135

CD84 was immunoprecipitated using:

Lane A:0.5 mg Raw264.7 Whole Cell Lysate

0.5 µL anti-CD84 rabbit monoclonal antibody and 15 μl of 50 % Protein G agarose.

Primary antibody:

Anti-CD84 rabbit monoclonal antibody,at 1:500 dilution

Secondary antibody:

Dylight 800-labeled antibody to rabbit IgG (H+L), at 1:5000 dilution

Developed using the odssey technique.

Performed under reducing conditions.

Predicted band size: 62 kDa

Observed band size: 62 kDa

Human CD84 Western blot (WB) 13117

Anti-CD84 rabbit monoclonal antibody at 1:500 dilution

Lane A: RAW264.7 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.


Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:39 kDa

Observed band size:39 kDa

Anti-CD84 Antibody Alternative Names
Anti-hCD84 Antibody;Anti-LY9B Antibody;Anti-mCD84 Antibody;Anti-SLAMF5 Antibody
CD84 Background Information

The CD2 family receptors are type I transmembrane glycoproteins belonging to immunoglobulin (Ig) superfamily characterized by a membrane-proximal Ig constant 2 (C2) domain and a membrane-distal variable (V) domain that is responsible for ligand recognition. CD84, also known as LY9B and SLAMF5, is a homophilic member of the SLAM (signaling lymphocyte activation molecule) subfamily of the CD2 family. The SLAM family receptorsmediate signal transduction through the interaction of its ITSM (immunoreceptor tyrosine-based switch motifs) in the intracellular region and the SH2 domain of adaptor molecules SAP (SLAM-associated protein) and EAT-2 (EWS-activated transcript 2), and accordingly modulate both adaptive and innate immune responses. The CD84-CD84 interaction was independent of its cytoplasmic tail. Thus, CD84 is its own ligand and acts as a costimulatory molecule. CD84 is expressed on cells from almost all hematopoietic lineages and on CD34+ hematopoietic progenitor cells, suggesting that CD84 serves as a marker for committed hematopoietic progenitor cells.

Full Name
CD84 molecule
  • Martin M, et al. (2001) CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma secretion: adhesion is mediated by Ig-like domain 1. J Immunol. 167(7): 3668-76.
  • Tangye SG, et al. (2002) CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2. Eur J Immunol. 32(6): 1640-9.
  • Zaiss M, et al. (2003) CD84 expression on human hematopoietic progenitor cells. Exp Hematol. 31(9): 798-805.
  • Tangye SG, et al. (2003) Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation. J Immunol. 171(5): 2485-95.
  • Yan Q, et al. (2007) Structure of CD84 provides insight into SLAM family function. Proc Natl Acad Sci U S A. 104(25): 10583-8.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CD84 Antibody Rabbit Polyclonal ELISA 50757-T16
    Anti-CD84 Antibody Rabbit Polyclonal ELISA 50757-RP01
    Anti-CD84 Antibody Mouse Monoclonal ELISA 10100-MM03
    Anti-CD84 Antibody Mouse Monoclonal ELISA(Det) 10100-MM05
    Anti-CD84 Antibody Rabbit Polyclonal ELISA 10100-RP02
    Anti-CD84 Antibody Rabbit Monoclonal ELISA,ELISA(Cap) 10100-R004
    Anti-CD84 Antibody Rabbit Polyclonal ELISA 10100-RP01
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