Anti-CD84 Antibody

Cat: 10100-RP02
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All CD84 Reagents
Anti-CD84 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-CD84 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human CD84
Immunogen
Recombinant Human CD84 protein (Catalog#10100-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human CD84 extracellular domain(rh CD84; Catalog#10100-H08H; Met 1-Gly 225; NP_003865.1). CD84 specific IgG was purified by human CD84 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CD84 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD84 Antibody Alternative Names
Anti-hCD84 Antibody;Anti-LY9B Antibody;Anti-mCD84 Antibody;Anti-SLAMF5 Antibody
CD84 Background Information

The CD2 family receptors are type I transmembrane glycoproteins belonging to immunoglobulin (Ig) superfamily characterized by a membrane-proximal Ig constant 2 (C2) domain and a membrane-distal variable (V) domain that is responsible for ligand recognition. CD84, also known as LY9B and SLAMF5, is a homophilic member of the SLAM (signaling lymphocyte activation molecule) subfamily of the CD2 family. The SLAM family receptorsmediate signal transduction through the interaction of its ITSM (immunoreceptor tyrosine-based switch motifs) in the intracellular region and the SH2 domain of adaptor molecules SAP (SLAM-associated protein) and EAT-2 (EWS-activated transcript 2), and accordingly modulate both adaptive and innate immune responses. The CD84-CD84 interaction was independent of its cytoplasmic tail. Thus, CD84 is its own ligand and acts as a costimulatory molecule. CD84 is expressed on cells from almost all hematopoietic lineages and on CD34+ hematopoietic progenitor cells, suggesting that CD84 serves as a marker for committed hematopoietic progenitor cells.

Full Name
CD84 molecule
References
  • Martin M, et al. (2001) CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma secretion: adhesion is mediated by Ig-like domain 1. J Immunol. 167(7): 3668-76.
  • Tangye SG, et al. (2002) CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2. Eur J Immunol. 32(6): 1640-9.
  • Zaiss M, et al. (2003) CD84 expression on human hematopoietic progenitor cells. Exp Hematol. 31(9): 798-805.
  • Tangye SG, et al. (2003) Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation. J Immunol. 171(5): 2485-95.
  • Yan Q, et al. (2007) Structure of CD84 provides insight into SLAM family function. Proc Natl Acad Sci U S A. 104(25): 10583-8.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CD84 Antibody Rabbit Polyclonal ELISA 50757-T16
    Anti-CD84 Antibody Rabbit Polyclonal ELISA 50757-RP01
    Anti-CD84 Antibody Mouse Monoclonal ELISA 10100-MM03
    Anti-CD84 Antibody Mouse Monoclonal ELISA(Det) 10100-MM05
    Anti-CD84 Antibody Rabbit Monoclonal ELISA,ELISA(Cap) 10100-R004
    Anti-CD84 Antibody Rabbit Monoclonal WB,ELISA,IP 10100-R006
    Anti-CD84 Antibody Rabbit Polyclonal ELISA 10100-RP01
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