Anti-CD83 Antibody

Cat: 11763-MM08
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All CD83 Reagents
Anti-CD83 Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-CD83 Antibody
Validated applications
ELISA,ELISA(Det)
Species reactivity
Reacts with: Human
Specificity
Human CD83
No cross-reactivity in ELISA with Mouse CD83 Human cell lysate (293 cell line)
Immunogen
Recombinant Human CD83 Protein (Catalog#11763-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD83 (rh CD83; Catalog#11763-H08H; Met 1-Ala 143). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG2b Clone #6H4G10
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CD83 Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  
ELISA(Det) 1:1000-1:10000 This antibody will detect Human CD83 in ELISA pair set (Catalog: # SEK11763). In a sandwich ELISA, it can be used as detection antibody when paired with (Catalog: # 11763-MM11).

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD83 Antibody Alternative Names
Anti-BL11 Antibody;Anti-HB15 Antibody
CD83 Background Information

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD83 is considered as a marker of mature dendritic cells as well as an adhesion receptor that binds to resting monocytes and a subset of activated CD8+ T cells. In certain conditions, CD83 tended to dimerize or even multimerize through its aberrant intermolecular disulfide bonds. The injection of CD83-Ig can significantly enhaunce the rate of tumor growth and inhibit the T cell growth.

Full Name
CD83 molecule
References
  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12
  • Scholler N, et al.(2002) Cutting Edge: CD83 Regulates the Development of Cellular Immunity. The Journal of Immunology. 168 (6): 2599-602.
  • Lechmann M, et al.(2002) CD83 on dendritic cells: more than just a marker for maturation. Trends in immunology. 23(6): 273-5.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CD83 Antibody Rabbit Polyclonal ELISA 90199-RP01
    Anti-CD83 Antibody Rabbit Polyclonal ELISA 90199-T16
    Anti-CD83 Antibody Rabbit Polyclonal ELISA 80333-RP01
    Anti-CD83 Antibody Rabbit Monoclonal ELISA 80333-R004
    Anti-CD83 Antibody Rabbit Polyclonal WB,ELISA 80333-T48
    Anti-CD83 Antibody Rabbit Polyclonal ELISA 50694-RP02
    Anti-CD83 Antibody Rabbit Monoclonal ELISA 50694-R005
    Anti-CD83 Antibody Mouse Monoclonal ELISA(Cap) 11763-MM11
    Anti-CD83 Antibody Rabbit Polyclonal ELISA,IHC-P 11763-T24
    Anti-CD83 Antibody Rabbit Polyclonal WB,ELISA 11763-RP01
    Anti-CD83 Antibody Rabbit Polyclonal WB,ELISA 11763-RP02
    Anti-CD83 Antibody Rabbit Monoclonal ELISA 11763-R017
    Anti-CD83 Antibody Rabbit Monoclonal WB 11763-R104
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