All CD82 reagents are produced in house and quality controlled, including 6 CD82 Antibody, 2 CD82 ELISA, 52 CD82 Gene, 1 CD82 IPKit, 1 CD82 Lysate, 1 CD82 Protein, 3 CD82 qPCR. All CD82 reagents are ready to use.
Recombinant CD82 proteins are expressed by HEK293 Cells with fusion tags as C-His.
CD82antibodies are validated with different applications, which are ELISA, ELISA(Cap), IHC-P, ELISA(Det), WB, IP.
CD82cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each CD82 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
CD82ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
CD82, also known as KAI-1, structurally belongs to tetraspanin family while categorised as metastasis suppressor gene on functional grounds. KAI1/CD82 is localized on cell membrane and form interactions with other tetraspanins, integrins and chemokines which are respectively responsible for cell migration, adhesion and signalling. Downregulation of CD82 expression is associated with the advanced stages of many human cancers and correlates with the acquisition of metastatic potential. Recent studies suggest that complex mechanisms underlie CD82 loss of function, including altered transcriptional regulation, splice variant production and post-translational protein modifications, and indicate a central role for CD82 in controlling metastasis as a 'molecular facilitator'. The loss of KAI1/CD82 expression in invasive and metastatic cancers is due to a complex, epigenetic mechanism that probably involves transcription factors such as NFkappaB, p53, and beta-catenin. A loss of KAI1 expression is also associated with the advanced stages of many human malignancies and results in the acquisition of invasive and metastatic capabilities by tumour cells. Thus, KAI1/CD82 is regarded as a wide-spectrum tumor metastasis suppressor.