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CD80/B7-1 Protein, Antibody, ELISA Kit, cDNA Clone

Mouse CD80/B7-1 Protein

Description: Active
Expression host: Human Cells
  • Slide 1
50446-M08H-100
50446-M08H-200
100 µg / $180
200 µg / $300
Add to Cart
Description: Active
Expression host: Human Cells
  • Slide 1
50446-M02H-100
50446-M02H-200
100 µg / $180
200 µg / $300
Add to Cart

Human CD80/B7-1 Protein

Description: Active
Expression host: Human Cells
  • Slide 1
10698-H03H-100
10698-H03H-200
100 µg / $200
200 µg / $300
Add to Cart
Expression host: Human Cells
  • Slide 1
10698-HCCH-100
10698-HCCH-200
100 µg / $200
200 µg / $300
Add to Cart
Description: Active
Expression host: Human Cells
  • Slide 1
10698-H08H-100
10698-H08H-200
100 µg / $200
200 µg / $300
Add to Cart

Cynomolgus CD80/B7-1 Protein

Expression host: Human Cells
  • Slide 1
90268-C02H-100
90268-C02H-200
100 µg / $180
200 µg / $300
Add to Cart
Expression host: Human Cells
  • Slide 1
  • Slide 1
90268-C08H-200
90268-C08H-100
200 µg / $300
100 µg / $180
Add to Cart

CD80/B7-1 Related Areas

CD80/B7-1 Related Pathways

CD80/B7-1 Related Product

    CD80/B7-1 Summary & Protein Information

    CD80/B7-1 Background

    Gene Summary: The protein encoded by this CD80 gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. CD80 can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]
    General information above from NCBI
    Subunit structure: Homodimer; CD80 dimers on the antigen presenting cells (APCs) bridge CTLA4/CD152 dimers on T-cells in a periodic zipper- like arrangement. Interacts with adenovirus subgroup B fiber proteins and acts as a receptor for these viruses.
    Subcellular location: Membrane; Single-pass type I membrane protein.
    Tissue specificity: Expressed on activated B-cells, macrophages and dendritic cells.
    Sequence similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.C
    General information above from UniProt

    The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.

    CD80/B7-1 Alternative Name

    CD80/B7-1 Related Studies

  • Greenfield EA, et al. (1998) CD28/B7 costimulation: a review. Crit Rev Immunol. 18(5): 389-418.
  • Zang X, et al. (2007) The B7 family and cancer therapy: costimulation and coinhibition. Clin Cancer Res. 13(18 Pt 1): 5271-9.
  • Mir MA, et al. (2008) Signaling through CD80: an approach for treating lymphomas. Expert Opin Ther Targets. 12(8): 969-79.
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