CD80 Protein & Antibody (B7-1 Protein)

Cluster of Differentiation 80 (B-lymphocyte activation antigen B7-1)

CD80 Products

CD80 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CD80/B7-1	Human	CD80/B7-1/Fc Protein, Recombinant	10698-H03H
CD80/B7-1	Human	CD80/B7-1 Protein, Recombinant	10698-H08H
CD80/B7-1	Human	CD80/B7-1 Protein, Recombinant	10698-HCCH
CD80/B7-1	Mouse	CD80/B7-1 Protein, Recombinant	50446-M08H
CD80/B7-1	Mouse	CD80 / B7-1 Protein, Recombinant	50446-M02H

  10698-H03H:  Measured by its ability to bind human CD28 in a functional Elisa.

CD80 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human CD80/B7-1	WB, ELISA	CD80 / B7-1 Antibody	10698-RP01
Human CD80/B7-1	WB, ELISA	CD80 / B7-1 Antibody (Antigen Affinity Purified)	10698-RP02
Human CD80/B7-1	WB, ELISA	CD80 / B7-1 Antibody	10698-MM01
Human CD80/B7-1	FCM	CD80 / B7-1 Antibody ( FITC )	10698-MM01-F

CD80 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CD80/B7-1	Human	Homo sapiens CD80/B7-1 cDNA Clone(NM_005191.3)	HG10698-M
CD80/B7-1	Mouse	Mouse B7-1/CD80 cDNA Clone / ORF Clone	MG50446-G
CD80/B7-1	Rat	Rattus norvegicus CD80/B7-1 cDNA Clone	RG80027-M

CD80 Related Areas

Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>CD80/B7-1

Immunology>>Adaptive Immunity>>T Cell>>T Cell Antigen Recognition>>CD80/B7-1

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD80/B7-1

Immunology>>Cluster of Differentiation>>Dendritic Cell CD Antigen>>Dendritic Cell Co-stimulatory Molecules>>CD80/B7-1

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers>>CD80/B7-1

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>T Cell Antigen Recognition>>CD80/B7-1

CD80 Alternative Names

CD80, B7-1, B7, CD28LG, CD28LG1, LAB7 [Homo sapiens]

Cd80, B71, Cd28l, Ly-53, Ly53, MIC17, TSA1 [Mus musculus]

CD80 Background

The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.

CD80 Related Studies

1. Greenfield EA, et al. (1998) CD28/B7 costimulation: a review. Crit Rev Immunol. 18(5): 389-418.
2. Zang X, et al. (2007) The B7 family and cancer therapy: costimulation and coinhibition. Clin Cancer Res. 13(18 Pt 1): 5271-9.
3. Mir MA, et al. (2008) Signaling through CD80: an approach for treating lymphomas. Expert Opin Ther Targets. 12(8): 969-79.