Anti-B7-1 Antibody (FITC)

Cat: 10698-MM01-F
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Anti-B7-1 Antibody (FITC) (Mouse Monoclonal antibody) General Information
Product name
Anti-B7-1 Antibody (FITC)
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human B7-1
Immunogen
Recombinant Human CD80 / B7-1 Protein (Catalog#10698-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD80 / B7-1 (rh CD80 / B7-1; Catalog#10698-H08H; NP_005182.1; Met 1-Asn 242) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Source
Monoclonal Mouse IgG1 Clone #01
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
FITC
Concentration
10 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Anti-B7-1 Antibody (FITC) (Mouse Monoclonal antibody) Validated Applications

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-B7-1 Antibody (FITC) (Mouse Monoclonal antibody) Images
Human CD80/B7-1 Flow Cytometry (FC) 2637
Profile of anti-B7-1 (CD80) reactivity on U937 cells analyzed by flow cytometry. Cells should be Fc-blocked by treatment with 20 μg of human IgG/106 cells for 1 hour at 4 ℃ prior to staining, washed, then stained with FITC Mouse anti-B7-1 (CD80).
Anti-B7-1 Antibody (FITC) Alternative Names
Anti-B7 Antibody;Anti-B7-1 Antibody;Anti-B7.1 Antibody;Anti-BB1 Antibody;Anti-CD28LG Antibody;Anti-CD28LG1 Antibody;Anti-LAB7 Antibody
B7-1 Background Information

The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.

Immune Checkpoint
Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: IHC Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Proteins
Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
CD80 molecule
References
  • Greenfield EA, et al. (1998) CD28/B7 costimulation: a review. Crit Rev Immunol. 18(5): 389-418.
  • Zang X, et al. (2007) The B7 family and cancer therapy: costimulation and coinhibition. Clin Cancer Res. 13(18 Pt 1): 5271-9.
  • Mir MA, et al. (2008) Signaling through CD80: an approach for treating lymphomas. Expert Opin Ther Targets. 12(8): 969-79.
  • Product Description Host Clonality Application Catalog# (PDF)
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    Anti-B7-1 Antibody (PE) Mouse Monoclonal FCM 10698-MM01-P
    Anti-B7-1 Antibody Rabbit Polyclonal ELISA 10698-T16
    Anti-B7-1 Antibody Rabbit Polyclonal ELISA 10698-RP01
    Anti-B7-1 Antibody Rabbit Polyclonal ELISA 10698-RP02
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