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CD80 / B7-1 Antibody, Rabbit PAb, Antigen Affinity Purified

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Human B7-1/CD80 Antibody Product Information
Immunogen:Recombinant Human CD80 / B7-1 protein (Catalog#10698-H08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Human CD80 / B7-1 (rh CD80 / B7-1; Catalog#10698-H08H; Met 1-Asn 242; NP_005182.1). CD80 / B7-1 specific IgG was purified by Human CD80 / B7-1 affinity chromatography.
Human B7-1/CD80 Antibody Usage Guide
Specificity:Human CD80 / B7-1
Application:ELISA

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human B7-1. The detection limit for Human B7-1 is approximately 0.00245 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other B7-1/CD80 Antibody Products
Reactivity: Human  
Application: FCM  
  • Slide 1
10698-MM01-50
10698-MM01-100
10698-MM01-200
50 µg 
100 µg 
200 µg 
Add to Cart
Reactivity: Human  
Application: ELISA  
    10698-RP01-100
    10698-RP01-200
    10698-RP01-400
    100 µg 
    200 µg 
     
    Add to Cart
    Reactivity: Human  
    Application: FCM  
    • Slide 1
    10698-MM01-F-50
    10698-MM01-F-100
    50 Tests 
    100 Tests 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  IHC-P  
    • Slide 1
    • Slide 1
    10698-T24-100
    10698-T24-50
    10698-T24-200
    100 µg 
    50 µg 
    200 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  WB  IHC-P  
    • Slide 1
    • Slide 1
    • Slide 1
    10698-T56-100
    10698-T56-50
    10698-T56-200
    100 µg 
    50 µg 
    200 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  IHC-P  
    • Slide 1
    10698-R775-100
    10698-R775-50
    100 µg 
    50 µg 
    Add to Cart
    Reactivity: Human  
    Application: FCM  
    • Slide 1
    10698-MM01-P-100
    10698-MM01-P-50
    100 Tests 
    50 Tests 
    Add to Cart
    Reactivity: Mouse  
    Application: ELISA  
      50446-R018-50
      50446-R018-100
      50 µg 
      100 µg 
      Add to Cart
      Reactivity: Mouse  
      Application: ELISA  
        50446-RP01-100
        50446-RP01-200
        50446-RP01-400
        100 µg 
        200 µg 
         
        Add to Cart
        Reactivity: Mouse  
        Application: ELISA  
          50446-RP02-50
          50446-RP02-100
          50446-RP02-200
          50 µg 
          100 µg 
          200 µg 
          Add to Cart
          Reactivity: Cynomolgus  
          Application: ELISA  
            90268-RP01-100
            90268-RP01-400
            90268-RP01-200
            100 µg 
             
            200 µg 
            Add to Cart
            Reactivity: Cynomolgus  
            Application: ELISA  
              90268-T16-200
              90268-T16-100
              90268-T16-50
              200 µg 
              100 µg 
              50 µg 
              Add to Cart
              CD80/B7-1 Background

              The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.

              Human CD80/B7-1 References
            • Greenfield EA, et al. (1998) CD28/B7 costimulation: a review. Crit Rev Immunol. 18(5): 389-418.
            • Zang X, et al. (2007) The B7 family and cancer therapy: costimulation and coinhibition. Clin Cancer Res. 13(18 Pt 1): 5271-9.
            • Mir MA, et al. (2008) Signaling through CD80: an approach for treating lymphomas. Expert Opin Ther Targets. 12(8): 969-79.
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              Catalog: 10698-RP02-50
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              All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
              Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"