Anti-B7-1 Antibody

Cat: 10698-MM01
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Anti-B7-1 Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-B7-1 Antibody
Validated applications
ELISA,FCM
Species reactivity
Reacts with: Human
Specificity
Human B7-1
No cross-reactivity in ELISA with Human CD28 Human B7-2 Human B7-H1 Mouse B7-H2 Human PDL2 Human cell lysate (293 cell line)
Immunogen
Recombinant Human CD80 / B7-1 Protein (Catalog#10698-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD80 / B7-1 (rh CD80 / B7-1; Catalog#10698-H08H; Met 1-Asn 242; NP_005182.1). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #01
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-B7-1 Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  
FCM 1:25-1:100  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-B7-1 Antibody (Mouse Monoclonal antibody) Images
Human CD80/B7-1 Flow Cytometry (FC) 5340
Flow cytometric analysis of Human B7-1(CD80) expression on Daudi cells. Cells were stained with purified anti-Human B7-1(CD80), then a FITC-conjugated second step antibody. The histogram were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Anti-B7-1 Antibody Alternative Names
Anti-B7 Antibody;Anti-B7-1 Antibody;Anti-B7.1 Antibody;Anti-BB1 Antibody;Anti-CD28LG Antibody;Anti-CD28LG1 Antibody;Anti-LAB7 Antibody
B7-1 Background Information

The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.

Immune Checkpoint
Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: IHC Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Proteins
Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
CD80 molecule
References
  • Greenfield EA, et al. (1998) CD28/B7 costimulation: a review. Crit Rev Immunol. 18(5): 389-418.
  • Zang X, et al. (2007) The B7 family and cancer therapy: costimulation and coinhibition. Clin Cancer Res. 13(18 Pt 1): 5271-9.
  • Mir MA, et al. (2008) Signaling through CD80: an approach for treating lymphomas. Expert Opin Ther Targets. 12(8): 969-79.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-B7-1 Antibody Rabbit Polyclonal ELISA 90268-T16
    Anti-B7-1 Antibody Rabbit Monoclonal ELISA 90268-R016
    Anti-B7-1 Antibody Rabbit Polyclonal ELISA 90268-RP01
    Anti-B7-1 Antibody Rabbit Polyclonal ELISA 50446-RP01
    Anti-B7-1 Antibody (FITC) Rabbit Monoclonal FCM 50446-R014-F
    Anti-B7-1 Antibody (APC) Rabbit Monoclonal FCM 50446-R009-A
    Anti-B7-1 Antibody Rabbit Polyclonal WB,ELISA 50446-T48
    Anti-B7-1 Antibody Rabbit Monoclonal ELISA 50446-R018
    Anti-B7-1 Antibody (PE) Rabbit Monoclonal FCM 50446-R009-P
    Anti-B7-1 Antibody Rabbit Monoclonal FCM 50446-R014
    Anti-B7-1 Antibody (PE) Rabbit Monoclonal FCM 50446-R014-P
    Anti-B7-1 Antibody Rabbit Monoclonal FCM 50446-R009
    Anti-B7-1 Antibody Rabbit Polyclonal ELISA 50446-RP02
    Anti-B7-1 Antibody Rabbit Monoclonal ELISA,IHC-P 10698-R775
    Anti-B7-1 Antibody Rabbit Polyclonal WB,ELISA,IHC-P 10698-T56
    Anti-B7-1 Antibody (PE) Mouse Monoclonal FCM 10698-MM01-P
    Anti-B7-1 Antibody Rabbit Polyclonal ELISA 10698-T16
    Anti-B7-1 Antibody Rabbit Polyclonal ELISA 10698-RP01
    Anti-B7-1 Antibody Rabbit Polyclonal ELISA 10698-RP02
    Anti-B7-1 Antibody Rabbit Polyclonal ELISA,IHC-P 10698-T24
    Anti-B7-1 Antibody (FITC) Mouse Monoclonal FCM 10698-MM01-F
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