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>Human Cell Expressed
>Rat CD79B / B29 Protein (His Tag)
|Catalog||Size (Price)||Quantity||In Stock||Operation|
Cd79b molecule, immunoglobulin-associated beta Protein Datasheet
CD79B / B29 Protein Price Inquiry ( Available Sizes )
CD79B / B29 Protein Product Information
|Synonym :||CD79B, B29/Ig-beta, Igb|
A DNA sequence encoding the rat CD79B(O70153)(Met1-Asp158) was expressed, fused with a polyhistidine tag at the C-terminus.
|Expression Host:||Human Cells|
CD79B / B29 Protein QC Testing
|Purity:||> 90 % as determined by SDS-PAGE||SDS-PAGE:
CD79B / B29 protein
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Val 26|
The recombinant rat CD79B comprises 144 amino acids and predicts a molecular mass of 16.8 kDa. The apparent molecular mass of the recombinant protein is approximately 28 kDa in SDS-PAGE under reducing conditions due to glycosylation.
|Formulation:||Lyophilized from sterile PBS, pH7.4.
CD79B / B29 Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
CD79B / B29 Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|CD79B||Mouse||CD79B Protein, Recombinant||50754-M08H|
|CD79B||Rat||CD79B / B29 Protein, Recombinant||80326-R02H|
|CD79B||Rat||CD79B / B29 Protein, Recombinant||80326-R08H|
CD79B / B29 Protein Description
B-cell antigen receptor complex-associated protein beta chain, also known as B-cell-specific glycoprotein B29, Ig-beta, Immunoglobulin-associated B29 protein, CD79b and B29, is a single-pass type I membrane protein which contains one Ig-like V-type ( immunoglobulin-like ) domain and one ITAM domain. CD79b / B29 is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. CD79b / B29 enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79b / B29 are the cause of agammaglobulinemia type 6 (AGM6) which is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development.
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- Wood WJ. et al., 1993, Genomics. 16: 187-92.
- Hashimoto S. et al., 1994, Immunogenetics. 40: 145-9.
- Radaev S. et al., 2010, Structure. 18: 934-43.
- Burkard TR. et al., 2011, BMC Syst Biol. 5: 17-17.