CD74 Protein & Antibody

Cluster of Differentiation 74

CD74 Products

CD74 Protein, Recombinant

Molecule	Species	Description	Cat. No
CD74	Human	CD74 Protein, Recombinant	11091-H07H

  11091-H07H:  Immobilized human CD74 at 5 µg/ml (100 µl/well) can bind biotinylated human CTSL1 with a linear range of 3.2-400 ng/ml. Measured by its binding ability in a functional ELISA.

CD74 Antibody

Molecule	Application	Description	Cat. No
Human CD74	WB, ELISA	Rabbit Polyclonal Antibody	11091-RP01
Human CD74	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	11091-RP02

CD74 cDNA Clone

Molecule	Species	Description	Cat. No
CD74	Human	Homo sapiens CD74 cDNA Clone	HG11091-M
CD74	Mouse	Mouse CD74 cDNA Clone / ORF Clone	MG50738-G

CD74 Related Areas

Cancer>>Cancer Stem Cell (CSC)>>CD74

Cancer>>Cancer Biomarkers>>CD74

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD74

Immunology>>Cluster of Differentiation>>Dendritic Cell CD Antigen>>Dendritic Cell Pathogen Recognition/Uptake>>CD74

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers / Monocyte Markers>>CD74

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Other>>CD74

CD74 Alternative Names

CD74, DHLAG, HLADG, Ia-GAMMA

CD74 Background

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD74, also known as HLA class2 histocompatibility antigen gamma chain and HLA-DR antigens-associated invariant chain, is a polypeptide involved in the formation and transport of MHC class2 protein. CD74 is expressed by B cells, macrophages, and Reed-Sternberg cells. When MHC class 2 protein was in the rough ER, its peptide-binding cleft was blocked by CD74 to prevent it from interacting with the endogenous peptides. CD74 also serves to facilitate MHC class2's export from ER.

CD74 Related Studies

1. Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
2. Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125–35.
3. Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
4. Moynes R, et al.  (1997) A marker to distinguish atypical fibroxanthoma from malignant fibrous histiocytoma. Cancer. 79 (11): 2115-24.
5. Gabrielle FA, et al. (2008) Regulation of dendritic cell migration by CD74, the MHC class 2-associated invariant chain. Science. 322 (5908): 1705-10.
6. Leng L, et al. (2003) MIF signal transduction initiated by binding to CD74. JEM.197 (11):  1467-76.