- EGFR Signaling Pathway
- TGF-beta Signaling
- Canonical Wnt Signaling
- non-Canonical Wnt Signaling
- Notch Signaling
- p53 Pathway
- NF-kB Pathway
- Cytokine Signaling
|Catalog||Size (Price)||Quantity||In Stock||Operation|
Cd70 molecule Protein Datasheet
CD70 Protein Price Inquiry ( Available Sizes )
CD70 Protein Product Information
A DNA sequence encoding the rat CD70(D3ZGU3) (Gln46-Pro195) was expressed, fused with Fc region of human IgG1 at the N-terminus.
|Expression Host:||Human Cells|
CD70 Protein QC Testing
|Purity:||> 95 % as determined by SDS-PAGE||SDS-PAGE:
|Immobilized mouse CD27-His (Cat:50110-M08H) at 10 μg/ml (100 μl/well) can bind rat Fc-CD70 with a linear range of 0.16-1.25 μg/ml.|
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Glu|
The recombinant rat CD70 comprises 410 amino acids and predicts a molecular mass of 45 kDa. The apparent molecular mass of the recombinant protein is approximately 55 kDa in SDS-PAGE under reducing conditions due to glycosylation.
|Formulation:||Lyophilized from sterile PBS, pH7.4.
CD70 Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
CD70 Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|CD70/CD27L/ TNFSF7||Human||CD70/CD27L/Fc Protein, Recombinant||10780-H01H|
|CD70/CD27L/ TNFSF7||Rat||CD70 Protein, Recombinant||80161-R01H|
|CD70/CD27L/ TNFSF7||Rat||CD70 Protein, Recombinant||80161-R07H|
CD70 Protein Description
CD70, also known as CD27 ligand (CD70 / CD27L / TNFSF7), is a member of the tumor necrosis factor superfamily (ie. TNFSF7) and a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. CD70 is a single-pass type Ⅲ transmebrane glycoprotin consisting of a short cytoplasmic domain (1-17aa) , a transmembrane domain (18-38 aa) and a 155aa extracellular domain (39-193), and exists as a homotrimer in vivo. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 expression on malignant cells coupled with its highly restricted expression on normal cells makes CD70 an attractive target for monoclonal antibody -based therapies.
- Goodwin RG. et al., 1993, Cell. 73: 447-56.
- Boursalian TE. et al., 2009, Adv Exp Med Biol. 647: 108-19.
- Bowman MR. et al., 1994, J Immunol. 152: 1756-61.
- McEarchern JA. et al., 2008, Clin Cancer Res. 14 (23): 7763-72.
- Tesselaar K. et al., 2002, J Immunol. 169: 33-40.
|Tumor Necrosis Factor (TNF) Family & Receptor|