All CD69 reagents are produced in house and quality controlled, including 6 CD69 Antibody, 1 CD69 ELISA, 39 CD69 Gene, 1 CD69 IPKit, 3 CD69 Lysate, 3 CD69 Protein, 3 CD69 qPCR. All CD69 reagents are ready to use.
Recombinant CD69 proteins are expressed by HEK293 Cells with fusion tags as C-His, N-human IgG1-Fc.
CD69antibodies are validated with different applications, which are ELISA, ELISA(Cap), ELISA(Det), WB, IP.
CD69cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each CD69 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
CD69ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
Early activation antigen CD69, also known as activation inducer molecule (AIM), is a single-pass type II membrane protein. Recently, cDNA clones encoding human and mouse CD69 were isolated and showed CD69 to be a member of the C-type lectin superfamily. It is one of the earliest cell surface antigens expressed by T cells following activation. Once expressed, CD69 acts as a costimulatory molecule for T cell activation and proliferation. In addition to mature T cells, CD69 is inducibly expressed by immature thymocytes, B cells, natural killer (NK) cells, monocytes, neutrophils and eosinophils, and is constitutively expressed by mature thymocytes and platelets. CD69 is involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets. The structure, chromosomal localization, expression and function of CD69 suggest that it is likely a pleiotropic immune regulator , potentially important in the activation and differentiation of a wide variety of hematopoietic cells. This membrane molecule transiently expresses on activated lymphocytes, and its selective expression in inflammatory infiltrates suggests that it plays a role in the pathogenesis of inflammatory diseases. CD69 plays a crucial role in the pathogenesis of allergen-induced eosinophilic airway inflammation and hyperresponsiveness and that CD69 could be a possible therapeutic target for asthmatic patients.