CD69 Protein & Antibody

Cluster of Differentiation 69

CD69 Products

CD69 Protein, Recombinant

Molecule	Species	Description	Cat. No
CD69	Human	CD69 Protein, Recombinant	11150-H08H

CD69 Antibody

Molecule	Application	Description	Cat. No
Human CD69	WB, ELISA	CD69 Antibody, Rabbit PAb	11150-RP01
Human CD69	WB, ELISA	CD69 Antibody, Rabbit PAb (Antigen Affinity Purified)	11150-RP02
Human CD69	WB, ELISA	CD69 Antibody	11150-R074
Human CD69	WB, ELISA	CD69 / AIM Antibody	11150-MM01

CD69 ELISA Kits

Molecule	Application	Description	Cat. No
Human CD69	ELISA	CD69 ELISA Pair Set, Human ELISA Pair Set	SEK11150

CD69 cDNA Clone

Molecule	Species	Description	Cat. No
CD69	Human	Homo sapiens CD69 cDNA Clone(NM_001781.2)	HG11150-M
CD69	Mouse	Mouse CD69 cDNA Clone / ORF Clone	MG50731-G
CD69	Rat	Rat CD69 cDNA Clone / ORF Clone	RG80209-G

CD69 Related Areas

Immunology>>Adaptive Immunity>>T Cell>>Regulatory T Cell>>CD69

Immunology>>Adhesion Molecule>>Lectin>>CD69

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD69

Immunology>>Cluster of Differentiation>>Granulocyte CD Antigen>>Eosinophils / Neutrophils>>CD69

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers>>CD69

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Regulatory T Cells>>CD69

CD69 Alternative Names

CD69, CLEC2C [Homo sapiens]

Cd69, 5830438K24Rik, AI452015, AIM, VEA [Mus musculus]

CD69 Background

Early activation antigen CD69, also known as activation inducer molecule (AIM), is a single-pass type II membrane protein. Recently, cDNA clones encoding human and mouse CD69 were isolated and showed CD69 to be a member of the C-type lectin superfamily. It is one of the earliest cell surface antigens expressed by T cells following activation. Once expressed, CD69 acts as a costimulatory molecule for T cell activation and proliferation. In addition to mature T cells, CD69 is inducibly expressed by immature thymocytes, B cells, natural killer (NK) cells, monocytes, neutrophils and eosinophils, and is constitutively expressed by mature thymocytes and platelets. CD69 is involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets. The structure, chromosomal localization, expression and function of CD69 suggest that it is likely a pleiotropic immune regulator , potentially important in the activation and differentiation of a wide variety of hematopoietic cells. This membrane molecule transiently expresses on activated lymphocytes, and its selective expression in inflammatory infiltrates suggests that it plays a role in the pathogenesis of inflammatory diseases. CD69 plays a crucial role in the pathogenesis of allergen-induced eosinophilic airway inflammation and hyperresponsiveness and that CD69 could be a possible therapeutic target for asthmatic patients.

CD69 Related Studies

1. Ziegler SF, et al. (1994) The activation antigen CD69. Stem Cells. 12(5): 456-65.
2. Marzio R, et al. (1999) CD69 and regulation of the immune function. Immunopharmacol Immunotoxicol. 21(3): 565-82.
3. Lamana A, et al. (2006) The role of CD69 in acute neutrophil-mediated inflammation. Eur J Immunol. 36(10): 2632-8.
4. Miki-Hosokawa T, et al. (2009) CD69 controls the pathogenesis of allergic airway inflammation. J Immunol. 183(12): 8203-15.