Anti-CD69 Antibody

Cat: 11150-MM01
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All CD69 Reagents
Anti-CD69 Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-CD69 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human CD69
Immunogen
Recombinant Human CD69 protein (Catalog#11150-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD69 extracellular domain (rh CD69; Catalog#11150-H08H; NP_001772.1; Ser 62-Lys 199). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #2B2F5E6
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CD69 Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 0.5-1 μg/mL  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD69 Antibody Alternative Names
Anti-AIM Antibody;Anti-BL-AC/P26 Antibody;Anti-CLEC2C Antibody;Anti-EA1 Antibody;Anti-GP32/28 Antibody;Anti-MLR-3 Antibody
CD69 Background Information

Early activation antigen CD69, also known as activation inducer molecule (AIM), is a single-pass type II membrane protein. Recently, cDNA clones encoding human and mouse CD69 were isolated and showed CD69 to be a member of the C-type lectin superfamily. It is one of the earliest cell surface antigens expressed by T cells following activation. Once expressed, CD69 acts as a costimulatory molecule for T cell activation and proliferation. In addition to mature T cells, CD69 is inducibly expressed by immature thymocytes, B cells, natural killer (NK) cells, monocytes, neutrophils and eosinophils, and is constitutively expressed by mature thymocytes and platelets. CD69 is involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets. The structure, chromosomal localization, expression and function of CD69 suggest that it is likely a pleiotropic immune regulator , potentially important in the activation and differentiation of a wide variety of hematopoietic cells. This membrane molecule transiently expresses on activated lymphocytes, and its selective expression in inflammatory infiltrates suggests that it plays a role in the pathogenesis of inflammatory diseases. CD69 plays a crucial role in the pathogenesis of allergen-induced eosinophilic airway inflammation and hyperresponsiveness and that CD69 could be a possible therapeutic target for asthmatic patients.

Full Name
CD69 molecule
References
  • Ziegler SF, et al. (1994) The activation antigen CD69. Stem Cells. 12(5): 456-65.
  • Marzio R, et al. (1999) CD69 and regulation of the immune function. Immunopharmacol Immunotoxicol. 21(3): 565-82.
  • Lamana A, et al. (2006) The role of CD69 in acute neutrophil-mediated inflammation. Eur J Immunol. 36(10): 2632-8.
  • Miki-Hosokawa T, et al. (2009) CD69 controls the pathogenesis of allergic airway inflammation. J Immunol. 183(12): 8203-15.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CD69 Antibody Rabbit Polyclonal ELISA 50731-T16
    Anti-CD69 Antibody Rabbit Polyclonal ELISA 11150-RP01
    Anti-CD69 Antibody Rabbit Polyclonal ELISA 11150-RP02
    Anti-CD69 Antibody Mouse Monoclonal ELISA,ELISA(Det) 11150-MM05
    Anti-CD69 Antibody Rabbit Monoclonal ELISA,ELISA(Cap) 11150-R006
    Anti-CD69 Antibody Rabbit Monoclonal WB,ELISA,IP 11150-R074
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