Anti-CD68 Antibody

Cat: 11192-RP02

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Anti-CD68 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-CD68 Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human CD68
Immunogen
Recombinant Human CD68 protein (Catalog#11192-H08B1)
Preparation
Produced in rabbits immunized with purified, recombinant Human CD68 (rh CD68; Catalog#11192-H08B1; P34810-1; Met1-Ser319). CD68 specific IgG was purified by Human CD68 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CD68 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  
IHC-P 1:5000-1:20000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD68 Antibody (Rabbit Polyclonal antibody) Images
Human CD68 Immunohistochemistry(IHC) 4479
Immunochemical staining of human CD68 in human lung with rabbit polyclonal antibody (1:10000, formalin-fixed paraffin embedded sections). Positive staining was localized to macrophages.
Human CD68 Immunohistochemistry(IHC) 4484
Immunochemical staining of human CD68 in human liver (cirrhosis) with rabbit polyclonal antibody (1:10000, formalin-fixed paraffin embedded sections).
Anti-CD68 Antibody Alternative Names
Anti-GP110 Antibody;Anti-LAMP4 Antibody;Anti-SCARD1 Antibody
CD68 Background Information

Macrosialin, also known as CD68 and Gp110, is a single-pass type I  membrane protein which belongs to the LAMP family. CD68 is highly expressed by blood monocytes and tissue macrophages. It is also expressed in lymphocytes, fibroblasts and endothelial cells. CD68 is expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. CD68 plays a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It is a commonly used marker for macrophages. However, a number of studies have shown that CD68 antibodies react with other hematopoietic and non-hematopoietic cell types, suggesting that CD68 may not be a macrophage-specific antigen. CD68 binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.

Full Name
CD68 molecule
References
  • Strobl H. et al., 1995, Br J Haematol. 90 (4): 774-82.
  • Ogawa Y. et al., 1995, Pathol Int. 45 (9): 698-701.
  • Sadovnikova E. et al., 2002,Leukemia. 16 (10): 2019-26.
  • Gottfried E. et al., 2008, Scand J Immunol. 67 (5): 453-63.
  • Strojnik T. et al., 2009, Anticancer Res. 29 (8): 3269-79.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CD68 Antibody Rabbit Monoclonal IHC-P 80307-R001
    Anti-CD68 Antibody Rabbit Polyclonal ELISA 80307-RP01
    Anti-CD68 Antibody Rabbit Polyclonal ELISA,IHC-P 80307-T24
    Anti-CD68 Antibody Rabbit Monoclonal ELISA 11192-R039
    Anti-CD68 Antibody Mouse Monoclonal IHC-P 11192-MM01
    Anti-CD68 Antibody Mouse Monoclonal ELISA 11192-MM06
    Anti-CD68 Antibody Rabbit Polyclonal WB,ELISA,IHC-P 11192-T56
    Anti-CD68 Antibody Mouse Monoclonal IHC-P 11192-MM11
    Anti-CD68 Antibody Rabbit Polyclonal ELISA,IHC-P 11192-T24
    Anti-CD68 Antibody Rabbit Monoclonal ELISA 11192-R175
    Anti-CD68 Antibody Rabbit Monoclonal IHC-P 11192-R179
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