CD64 (FCGR1)

CD64 is a high affinity receptor for the Fc region of immunoglobulins gamma. CD64 functions in both innate and adaptive immune responses.

CD64 (FCGR1) Related Areas

Cancer>>Cancer Stem Cell (CSC)>>CD64/FCGR1

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers / Monocyte Markers>>CD64/FCGR1

Immunology>>Fc Receptor>>CD64/FCGR1

CD64 (FCGR1) Alternative Names

CD64, FCGR1, FCGR1A, FCGR1B, FCGR1C, FCRI, FLJ18345, RP11-439A17.1, IGFR1, IGFRB, IGFRC [Homo sapiens]

CD64, Fcgr1, AI323638, AV092959, FcgammaRI, IGGHAFC [Mus musculus]

Summaries for CD64 (FCGR1)

Entrez Gene summary for FCGR1A:

This FCGR1A gene encodes a protein that plays an important role in the immune response. CD64 is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008]

Entrez Gene summary for FCGR1B:

Three distinct, but closely related classes of receptors that bind the Fc portion of IgG have been identified (Fcgamma RI, II and III). The FcgammaRI family consists of three closely related genes termed A, B, and C. This FCGR1B gene encodes the low affinity FcgammaRIB receptor that may play an important role in humoral immune response. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Wikipedia summary for CD64:

CD64 (Cluster of Differentiation 64) is a type of integral membrane glycoprotein known as an Fc receptor that binds monomeric IgG-type antibodies with high affinity. CD64 is more commonly known as Fc-gamma receptor 1 (FcγRI). After binding IgG, CD64 interacts with an accessory chain known as the common γ chain (γ chain), which possesses an ITAM motif that is necessary for triggering cellular activation.

Structurally CD64 is composed of a signal peptide that allows its transport to the surface of a cell, three extracellular immunoglobulin domains of the C2-type that it uses to bind antibody, a hydrophobic transmembrane domain, and a short cytoplasmic tail.

CD64 is constitutively found on only macrophages and monocytes, but treatment of polymorphonuclear leukocytes with cytokines like IFNγ and G-CSF can induce CD64 expression on these cells

There are three distinct (but highly similar) genes in humans for CD64 called FcγRIA (CD64A), FcγRIB (CD64B), and FcγRIC (CD64C) that are located on chromosome 1. These three genes produce six different mRNA transcripts ; two from CD64A, three from CD64B, and one from CD64C; by alternate splicing of the genes.

Human CD64 (FCGR1) Protein General Information

 

• Protein names: High affinity immunoglobulin gamma Fc receptor I
• Sequence length: 374 AA.
• Sequence similarities: CD64 belongs to the immunoglobulin superfamily. FCGR1 family. CD64 contains 3 Ig-like C2-type (immunoglobulin-like) domains.
• Post-translational modification: Phosphorylated on serine residues
• Subunit structure: CD64 interacts with FCERG1; forms a functional signaling complex. CD64 interacts with FLNA; prevents FCGR1A degradation. Interacts with EPB41L2, LAT and PPL. CD64 interacts with HCK and LYN.
• Subcellular location: Cell membrane; Single-pass type I membrane protein. Note: Stabilized at the cell membrane through interaction with FCER1G.
• Tissue specificity: Monocyte/macrophage specific.

General information above from UniProt

Function for CD64 (FCGR1) Protein

UniProtKB:

CD64 is a high affinity receptor for the Fc region of immunoglobulins gamma. CD64 functions in both innate and adaptive immune responses.

Genatlas:

• CD64 acts as a receptor for the Fc domain of IgG
• CD64 has a role in immune response
• CD64 plays an important role in the internalization of Mycobacterium tuberculosis into macrophages (Pubmed 18279703)
• CD64 can mediate phagocytosis of opsonized pathogens, but can also effectively capture small immune complexes, and facilitates antigen presentation (Pubmed 18023480)
• CD64 has the capacity to mediate potent antimalaria immunity (Pubmed 17511516)

Homology for human CD64 (FCGR1)

• homolog to rattus Rn.16643
• homolog to murine Fcgr1
• homolog to C.elegans B0412.1

Phenotype Information for CD64 (FCGR1)

• Gene/Locus: FCGR1A, IGFR1, CD64
• Phenotype: [IgG receptor I, phagocytic, familial deficiency of]

Phenotype Information for CD64 from OMIM (Online Mendelian Inheritance in Man)