CD63 Protein

Cluster of Differentiation 63

CD63 Products

CD63 Protein, Recombinant

Molecule	Species	Description	Cat. No
CD63	Human	CD63 / Tspan-30 / Tetraspanin-30 Protein, Recombinant	11271-H08H
CD63	Sus scrofa (Pig)	CD63 / Tspan-30 / Tetraspanin-30 Protein, Recombinant	13657-W02H

CD63 cDNA Clone

Molecule	Species	Description	Cat. No
CD63	Human	CD63 cDNA Clone / ORF Clone	HG11271-M
CD63	Mouse	CD63 cDNA Clone / ORF Clone	MG50557-M
CD63	Rat	CD63 cDNA Clone / ORF Clone	RG80304-G

CD63 Related Areas

Cardiovascular>>Platelet>>CD63

Immunology>>Adhesion Molecule>>Extracellular Matrix Molecule>>Extracellular Matrix Protein>>CD63

Immunology>>Cluster of Differentiation>>CD63

CD63 Alternative Names

CD63, LAMP-3, ME491, MLA1, OMA81H, TSPAN30 [Homo sapiens]

Cd63, C75951, ME491, MGC103180, MGC107286, Tspan30 [Mus musculus]

CD63 Background

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 63 (CD63) is a member of the CD family and the transmembrane 4 superfamily,also known as the tetraspanin family. CD63 is a cellular surface glycoprotein characterized by the presence of four bydrophobic domains. CD63 had functions in mediating signal transduction processes and then regulate variety of cellular processes such as cell proliferation, activation and motility. It has reported that CD63 protein associated with tumor progression and served as a blood platlet activation marker and the deficiency of this protein may be associated with Hermansky-Pudlak syndrome.

CD63 Related Studies

1. Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
2. Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125–35.
3. Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
4. Radford KJ, et al. (1996) Associates with Transmembrane 4 Superfamily Members, CD9 and CD81, and with β1 Integrins in Human Melanoma. Biochemical Biophysical Research Communications. 222(1): 13-18.
5. Metzelaar MJ, et al. (1991) CD63 antigen, A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells. The journal of biological chemistry. 266: 3239-45.