Anti-CD63 Antibody

Cat: 11271-MM10
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Anti-CD63 Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-CD63 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human CD63
No cross-reactivity in ELISA with Human cell lysate (293 cell line)
Immunogen
Recombinant Human CD63 protein (Catalog#11271-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD63 (rh CD63; Catalog#11271-H08H; P08962-1; Ala 103-Val 203). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #10
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CD63 Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD63 Antibody Alternative Names
Anti-LAMP-3 Antibody;Anti-ME491 Antibody;Anti-MLA1 Antibody;Anti-OMA81H Antibody;Anti-TSPAN30 Antibody
CD63 Background Information

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 63 (CD63) is a member of the CD family and the transmembrane 4 superfamily,also known as the tetraspanin family. CD63 is a cellular surface glycoprotein characterized by the presence of four bydrophobic domains. CD63 had functions in mediating signal transduction processes and then regulate variety of cellular processes such as cell proliferation, activation and motility. It has reported that CD63 protein associated with tumor progression and served as a blood platlet activation marker and the deficiency of this protein may be associated with Hermansky-Pudlak syndrome.

Full Name
CD63 molecule
References
  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
  • Radford KJ, et al. (1996) Associates with Transmembrane 4 Superfamily Members, CD9 and CD81, and with beta 1 Integrins in Human Melanoma. Biochemical Biophysical Research Communications. 222(1): 13-18.
  • Metzelaar MJ, et al. (1991) CD63 antigen, A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells. The journal of biological chemistry. 266: 3239-45.
  • Product Description Host Clonality Application Catalog# (PDF)
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    Anti-CD63 Antibody Rabbit Monoclonal ELISA 11271-R142
    Anti-CD63 Antibody (PE) Mouse Monoclonal FCM 11271-MM03-P
    Anti-CD63 Antibody Rabbit Polyclonal IHC-P 11271-RP02
    Anti-CD63 Antibody (APC) Mouse Monoclonal FCM 11271-MM12-A
    Anti-CD63 Antibody Mouse Monoclonal FCM,ICC/IF,IF 11271-MM12
    Anti-CD63 Antibody Mouse Monoclonal IHC-P 11271-MM01
    Anti-CD63 Antibody Rabbit Monoclonal IHC-P 11271-R001
    Anti-CD63 Antibody (FITC) Mouse Monoclonal FCM 11271-MM12-F
    Anti-CD63 Antibody Rabbit Polyclonal ELISA 11271-T16
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