CD62L Protein & Antibody (L-Selectin, SELL)

CD62 Antigen-Like Family Member L

CD62L Products

CD62L Protein, Recombinant

Molecule	Species	Description	Cat. No
CD62L/L-Selectin	Human	CD62L/L-Selectin Protein, Recombinant	11838-H08H
CD62L/L-Selectin	Mouse	CD62L/L-Selectin/Fc Protein, Recombinant	50045-M03H
CD62L/L-Selectin	Mouse	CD62L/L-Selectin Protein, Recombinant	50045-M08H

  11838-H08H:  Measured by its ability to bind biotinylated human CD34 in a functional ELISA.

  50045-M03H:  When cells are added to SELL coated plates (10 µg/mL, 100 µL/well) approximately 90%-100% will adhere specifically. Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells.

CD62L Antibody

Molecule	Application	Description	Cat. No
Human CD62L/L-Selectin	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	11838-RP02
Mouse CD62L/L-Selectin	WB, ELISA	Rabbit Polyclonal Antibody	50045-RP01
Mouse CD62L/L-Selectin	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	50045-RP02
Mouse CD62L/L-Selectin	WB, ELISA	SELL / CD62L / L-selectin Antibody	50045-R022
Mouse CD62L/L-Selectin	FCM	SELL / CD62L / L-selectin Antibody ( FITC )	50045-R414-F

CD62L Elisa Pair Set

Molecule	Application	Description	Cat. No
Mouse CD62L/L-Selectin	ELISA	CD62L Elisa Pair Set	SEK50045

CD62L cDNA Clone

Molecule	Species	Description	Cat. No
CD62L/L-Selectin	Mouse	Mus musculus CD62L/L-Selectin cDNA Clone	MG50045-M
CD62L/L-Selectin	Rat	Rattus norvegicus CD62L/L-Selectin cDNA	RG80046-M

CD62L Alternative Names

CD62L, L-Selectin, SELL, AI528707, LECAM-1, Lnhr, Ly-22, Ly-m22, Lyam-1, Lyam1

CD62L Related Areas

Immunology>>Adaptive Immunity>>T Cell>>Regulatory T Cell / T Cell Migration/Adhesion>>CD62L/L-Selectin

Immunology>>Adhesion Molecule>>Lectin>>CD62L/L-Selectin

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD62L/L-Selectin

Immunology>>Cluster of Differentiation>>Granulocyte CD Antigen>>Granulocyte Markers>>CD62L/L-Selectin

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Monocyte Markers>>CD62L/L-Selectin

Immunology>>Cluster of Differentiation>>Natural Killer (NK) Cell CD Antigen>>CD62L/L-Selectin

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Regulatory T Cells / T Cell Migration/Adhesion>>CD62L/L-Selectin

CD62L Background

L-selectin (SELL), also known as CD62L, is a key adhesion molecule that regulates both the migration of leukocytes at sites of inflammation and the recirculation of lymphocytes between blood and lymphoid tissues. It belongs to the selectin family of proteins, and consisting of a large, highly glycosylated, extracellular domain, a single spanning transmembrane domain and a small cytoplasmic tail. L-selectin is the only selectin expressed on leukocytes and mediates a number of leukocyte-endothelial interactions. L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to leukocyte expressing L-selectin, slowing leukocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point. L-selectin-mediated lymphocyte recirculation is required for maintaining the appropriate tissue distribution of lymphocyte subpopulations including naïve and effector subsets such as regulatory T cells. In addition, L-selectin-mediated entry into peripheral lymph nodes is required for optimal induction of lymphocyte homeostatic proliferation during lymphopenia. Importantly, L-selectin has been shown to have both adhesive and signaling functions during leukocyte migration. L-selectin has also been shown to mediate leukocyte recruitment during chronic inflammatory and autoimmune diseases and thus is a potential therapeutic target for drug development.

CD62L Related Studies

1. Smalley DM, et al. (2005) L-selectin: mechanisms and physiological significance of ectodomain cleavage. J Cell Mol Med. 9(2): 255-66.
2. Grailer JJ, et al. (2009) L-selectin: role in regulating homeostasis and cutaneous inflammation. J Dermatol Sci. 56(3): 141-7.