All CD6 reagents are produced in house and quality controlled, including 18 CD6 Antibody, 2 CD6 ELISA, 39 CD6 Gene, 4 CD6 Lysate, 4 CD6 Protein, 2 CD6 qPCR. All CD6 reagents are ready to use.
Recombinant CD6 proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc, C-His.
CD6antibodies are validated with different applications, which are FCM, ELISA(Cap), ICC/IF, IF, ELISA, IHC-P, ELISA(Det).
CD6cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each CD6 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
CD6ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
T-cell differentiation antigen CD6, also known as TP120 and CD6, is a single-pass type I membrane protein which contains three SRCR domains. CD6 / TP120 is a cell surface glycoprotein expressed primarily on T cells, it may function as a costimulatory molecule and may play a role in autoreactive immune responses. CD6 / TP120 is expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. CD6 ligand termed CD166 (previously known as activated leukocyte cell adhesion molecule, ALCAM ) has been identified and shown to be expressed on activated T cells, B cells, thymic epithelium, keratinocytes, and in rheumatoid arthritis synovial tissue. CD6 / TP120 binds to activated leukocyte cell adhesion molecule ( CD166 ), and is considered as a costimulatory molecule involved in lymphocyte activation and thymocyte development. CD6 / TP120 partially associates with the TCR / CD3 complex and colocalizes with it at the center of the mature immunological synapse (IS) on T lymphocytes. During thymic development CD6-dependent signals may contribute both to thymocyte survival, and to the overall functional avidity of selection in both man and mouse.