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CD6 / Cluster of Differentiation 6 Protein, Antibody, ELISA Kit, cDNA Clone

CD6 / Cluster of Differentiation 6 Related Areas

CD6 / Cluster of Differentiation 6 Related Pathways

CD6 / Cluster of Differentiation 6 Related Product

    CD6 / Cluster of Differentiation 6 Summary & Protein Information

    CD6 / Cluster of Differentiation 6 Background

    Gene Summary: This CD6 gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. CD6 contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This CD6 gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
    General information above from NCBI
    Subcellular location: Membrane; Single-pass type I membrane protein.
    Tissue specificity: Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain.
    Post-translational: After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues and phosphorylated on Tyr residues.
    Contains intrachain disulfide bond(s).
    Sequence similarity: Contains 3 SRCR domains.C
    General information above from UniProt

    T-cell differentiation antigen CD6, also known as TP120 and CD6, is a single-pass type I membrane protein which contains three SRCR domains. CD6 / TP120 is a cell surface glycoprotein expressed primarily on T cells, it may function as a costimulatory molecule and may play a role in autoreactive immune responses. CD6 / TP120 is expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. CD6 ligand termed CD166 (previously known as activated leukocyte cell adhesion molecule, ALCAM ) has been identified and shown to be expressed on activated T cells, B cells, thymic epithelium, keratinocytes, and in rheumatoid arthritis synovial tissue. CD6 / TP120 binds to activated leukocyte cell adhesion molecule ( CD166 ), and is considered as a costimulatory molecule involved in lymphocyte activation and thymocyte development. CD6 / TP120 partially associates with the TCR / CD3 complex and colocalizes with it at the center of the mature immunological synapse (IS) on T lymphocytes. During thymic development CD6-dependent signals may contribute both to thymocyte survival, and to the overall functional avidity of selection in both man and mouse.

    CD6 / Cluster of Differentiation 6 Alternative Name

    FLJ44171,TP120,CD6, [human]
    Cd6, [mouse]

    CD6 / Cluster of Differentiation 6 Related Studies

  • Joo YS. et al., 2000, Arthritis Rheum. 43 (2): 329-35.
  • Singer NG. et al., 2002, Int Immunol. 14 (6): 585-97.
  • Gimferrer I. et al., 2005, J Immunol. 175 (3): 1406-14.
  • Alonso R. et al., 2010, J Autoimmun. 35 (4): 336-41.
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