CD6 (Protein | Antibody | cDNA Clone | ELISA Kit)

All CD6 reagents are produced in house and quality controlled, including 19 CD6 Antibody, 2 CD6 ELISA, 39 CD6 Gene, 4 CD6 Lysate, 4 CD6 Protein, 2 CD6 qPCR. All CD6 reagents are ready to use.

CD6 Protein (4)

CD6 Antibody (19)

CD6 ELISA Kit & Match Antibody ELISA Pair Set ( 2 )

CD6 cDNA Clone (39)

XM_011545360.1
NM_009852.3
NM_175577.3

CD6 Lysate (4)

CD6 Background

T-cell differentiation antigen CD6, also known as TP12 and CD6, is a single-pass type I membrane protein which contains threeSRCR domains. CD6 / TP12 is a cell surface glycoprotein expressed primarily on T cells, it may function as a costimulatory molecule and may play a role in autoreactive immune responses. CD6 / TP12 is expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. CD6 ligand termed CD166 (previously known as activated leukocyte cell adhesion molecule, ALCAM ) has been identified and shown to be expressed on activated T cells, B cells, thymic epithelium, keratinocytes, and in rheumatoid arthritis synovial tissue. CD6 / TP12 binds to activated leukocyte cell adhesion molecule ( CD166 ), and is considered as a costimulatory molecule involved in lymphocyte activation and thymocyte development. CD6 / TP12 partially associates with the TCR / CD3 complex and colocalizes with it at the center of the mature immunological synapse (IS) on T lymphocytes. During thymic development CD6-dependent signals may contribute both to thymocyte survival, and to the overall functional avidity of selection in both man and mouse.

CD6 References

  • Joo YS. et al., 2000, Arthritis Rheum. 43 (2): 329-35.
  • Singer NG. et al., 2002, Int Immunol. 14 (6): 585-97.
  • Gimferrer I. et al., 2005, J Immunol. 175 (3): 1406-14.
  • Alonso R. et al., 2010, J Autoimmun. 35 (4): 336-41.