Anti-CD6 Antibody (PE)

Cat: 50711-R021-P
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Anti-CD6 Antibody (PE) (Rabbit Monoclonal antibody) General Information
Product name
Anti-CD6 Antibody (PE)
Validated applications
FCM
Species reactivity
Reacts with: Mouse
Specificity
Mouse CD6
Immunogen
Recombinant Mouse CD6 protein (Catalog#50711-M08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD6 (rM CD6; Catalog#50711-M08H; Q91WN5; Met1-Gly396) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Source
Monoclonal Rabbit IgG Clone #021
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
PE
Concentration
2 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Anti-CD6 Antibody (PE) (Rabbit Monoclonal antibody) Validated Applications

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD6 Antibody (PE) (Rabbit Monoclonal antibody) Images
Mouse CD6 / Cluster of Differentiation 6 Flow Cytometry (FC) 4960
Analysis of CD6 expression on spleen lymphocytes.
CD6 Background Information

T-cell differentiation antigen CD6, also known as TP120 and CD6, is a single-pass type I membrane protein which contains three SRCR domains. CD6 / TP120 is a cell surface glycoprotein expressed primarily on T cells, it may function as a costimulatory molecule and may play a role in autoreactive immune responses. CD6 / TP120 is expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. CD6 ligand termed CD166 (previously known as activated leukocyte cell adhesion molecule, ALCAM ) has been identified and shown to be expressed on activated T cells, B cells, thymic epithelium, keratinocytes, and in rheumatoid arthritis synovial tissue. CD6 / TP120 binds to activated leukocyte cell adhesion molecule ( CD166 ), and is considered as a costimulatory molecule involved in lymphocyte activation and thymocyte development. CD6 / TP120 partially associates with the TCR / CD3 complex and colocalizes with it at the center of the mature immunological synapse (IS) on T lymphocytes. During thymic development CD6-dependent signals may contribute both to thymocyte survival, and to the overall functional avidity of selection in both man and mouse.

Full Name
CD6 molecule
References
  • Joo YS. et al., 2000, Arthritis Rheum. 43 (2): 329-35.
  • Singer NG. et al., 2002, Int Immunol. 14 (6): 585-97.
  • Gimferrer I. et al., 2005, J Immunol. 175 (3): 1406-14.
  • Alonso R. et al., 2010, J Autoimmun. 35 (4): 336-41.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CD6 Antibody (PE) Mouse Monoclonal FCM 80311-MM01-P
    Anti-CD6 Antibody Mouse Monoclonal FCM 80311-MM01
    Anti-CD6 Antibody (APC) Mouse Monoclonal FCM 80311-MM01-A
    Anti-CD6 Antibody Rabbit Polyclonal ELISA,IHC-P 80311-T24
    Anti-CD6 Antibody Mouse Monoclonal ELISA,IHC-P 80311-MM03
    Anti-CD6 Antibody (FITC) Mouse Monoclonal FCM 80311-MM01-F
    Anti-CD6 Antibody Rabbit Polyclonal ELISA 50711-T16
    Anti-CD6 Antibody Rabbit Monoclonal ELISA(Det) 50711-R002
    Anti-CD6 Antibody Rabbit Polyclonal ELISA 50711-RP02
    Anti-CD6 Antibody (APC) Rabbit Monoclonal FCM 50711-R021-A
    Anti-CD6 Antibody Rabbit Monoclonal ELISA 50711-R309
    Anti-CD6 Antibody (FITC) Rabbit Monoclonal FCM 50711-R021-F
    Anti-CD6 Antibody Rabbit Monoclonal ICC/IF,IF 50711-R001
    Anti-CD6 Antibody Rabbit Monoclonal ELISA(Cap) 50711-R039
    Anti-CD6 Antibody (PerCP) Rabbit Monoclonal FCM 50711-R021-C
    Anti-CD6 Antibody Rabbit Monoclonal FCM 50711-R021
    Anti-CD6 Antibody Rabbit Polyclonal ELISA 50711-RP01
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