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CD6 Antibody (FITC), Rabbit MAb

  • Mouse CD6 / Cluster of Differentiation 6 Flow Cytometry (FC) 4960
  • CD6 Antibody (FITC), Rabbit MAb, Flow cytometric
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Mouse CD6 Antibody Product Information
Immunogen:Recombinant Mouse CD6 protein (Catalog#50422-M08H)
Clone ID:021
Ig Type:Rabbit IgG
Concentration:2 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD6 (rM CD6; Catalog#50422-M08H; NP_001153030.1; Gly30-Lys439) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Mouse CD6 Antibody FC Application Image
CD6 Antibody (FITC), Rabbit MAb, Flow cytometric
[Click to enlarge image]
Caption:
Analysis of CD6 expression on spleen lymphocytes.
Other CD6 Antibody Products
CD6 / Cluster of Differentiation 6 Background

T-cell differentiation antigen CD6, also known as TP120 and CD6, is a single-pass type I membrane protein which contains three SRCR domains. CD6 / TP120 is a cell surface glycoprotein expressed primarily on T cells, it may function as a costimulatory molecule and may play a role in autoreactive immune responses. CD6 / TP120 is expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. CD6 ligand termed CD166 (previously known as activated leukocyte cell adhesion molecule, ALCAM ) has been identified and shown to be expressed on activated T cells, B cells, thymic epithelium, keratinocytes, and in rheumatoid arthritis synovial tissue. CD6 / TP120 binds to activated leukocyte cell adhesion molecule ( CD166 ), and is considered as a costimulatory molecule involved in lymphocyte activation and thymocyte development. CD6 / TP120 partially associates with the TCR / CD3 complex and colocalizes with it at the center of the mature immunological synapse (IS) on T lymphocytes. During thymic development CD6-dependent signals may contribute both to thymocyte survival, and to the overall functional avidity of selection in both man and mouse.

Mouse CD6 / Cluster of Differentiation 6 References
  • Joo YS. et al., 2000, Arthritis Rheum. 43 (2): 329-35.
  • Singer NG. et al., 2002, Int Immunol. 14 (6): 585-97.
  • Gimferrer I. et al., 2005, J Immunol. 175 (3): 1406-14.
  • Alonso R. et al., 2010, J Autoimmun. 35 (4): 336-41.
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    Catalog: 50711-R021-F-100
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    100 Tests
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    Datasheet & Documentation

    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"