Anti-CD6 Antibody

Cat: 50711-R309
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Anti-CD6 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-CD6 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse CD6
Immunogen
Recombinant Mouse CD6 protein (Catalog#50711-M08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD6 (rM CD6; Catalog#50711-M08H; Q91WN5; Met 1-Val 243).
Source
Monoclonal Rabbit IgG Clone #309
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CD6 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

CD6 Background Information

T-cell differentiation antigen CD6, also known as TP120 and CD6, is a single-pass type I membrane protein which contains three SRCR domains. CD6 / TP120 is a cell surface glycoprotein expressed primarily on T cells, it may function as a costimulatory molecule and may play a role in autoreactive immune responses. CD6 / TP120 is expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. CD6 ligand termed CD166 (previously known as activated leukocyte cell adhesion molecule, ALCAM ) has been identified and shown to be expressed on activated T cells, B cells, thymic epithelium, keratinocytes, and in rheumatoid arthritis synovial tissue. CD6 / TP120 binds to activated leukocyte cell adhesion molecule ( CD166 ), and is considered as a costimulatory molecule involved in lymphocyte activation and thymocyte development. CD6 / TP120 partially associates with the TCR / CD3 complex and colocalizes with it at the center of the mature immunological synapse (IS) on T lymphocytes. During thymic development CD6-dependent signals may contribute both to thymocyte survival, and to the overall functional avidity of selection in both man and mouse.

Full Name
CD6 molecule
References
  • Joo YS. et al., 2000, Arthritis Rheum. 43 (2): 329-35.
  • Singer NG. et al., 2002, Int Immunol. 14 (6): 585-97.
  • Gimferrer I. et al., 2005, J Immunol. 175 (3): 1406-14.
  • Alonso R. et al., 2010, J Autoimmun. 35 (4): 336-41.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CD6 Antibody (PE) Mouse Monoclonal FCM 80311-MM01-P
    Anti-CD6 Antibody (FITC) Mouse Monoclonal FCM 80311-MM01-F
    Anti-CD6 Antibody Mouse Monoclonal ELISA,IHC-P 80311-MM03
    Anti-CD6 Antibody Mouse Monoclonal FCM 80311-MM01
    Anti-CD6 Antibody Rabbit Polyclonal ELISA,IHC-P 80311-T24
    Anti-CD6 Antibody (APC) Mouse Monoclonal FCM 80311-MM01-A
    Anti-CD6 Antibody Rabbit Polyclonal ELISA 50711-T16
    Anti-CD6 Antibody Rabbit Monoclonal ELISA(Det) 50711-R002
    Anti-CD6 Antibody Rabbit Polyclonal ELISA 50711-RP02
    Anti-CD6 Antibody (APC) Rabbit Monoclonal FCM 50711-R021-A
    Anti-CD6 Antibody (PerCP) Rabbit Monoclonal FCM 50711-R021-C
    Anti-CD6 Antibody Rabbit Monoclonal ELISA(Cap) 50711-R039
    Anti-CD6 Antibody (PE) Rabbit Monoclonal FCM 50711-R021-P
    Anti-CD6 Antibody Rabbit Monoclonal ICC/IF,IF 50711-R001
    Anti-CD6 Antibody (FITC) Rabbit Monoclonal FCM 50711-R021-F
    Anti-CD6 Antibody Rabbit Monoclonal FCM 50711-R021
    Anti-CD6 Antibody Rabbit Polyclonal ELISA 50711-RP01
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