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CD59a / Protectin  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Human Cells  
50724-M08H-50
50724-M08H-20
50 µg 
20 µg 
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  • Slide 1
Expression host: Human Cells  
50724-M02H-50
50724-M02H-20
50 µg 
20 µg 
Add to Cart
  • Slide 1

CD59a / Protectin Related Area

CD59a / Protectin Related Pathways

    CD59a / Protectin Summary & Protein Information

    CD59a / Protectin Background

    Protectin, a complement regulatory protein, also known as CD59, or MIRL (membrane inhibitor of reactive lysis) is a small protein that inhibits the complement membrane attack complex by binding C5b678 and preventing C9 from binding and polymerizing. The amino-terminal 25 amino acids represented a typical signal peptide sequence and the carboxy-terminal hydrophobic amino acids were characteristic for phosphatidylinositol-anchored proteins.It was found that the CD59/Protectin antigen is a small protein sometimes associated with larger components (45 and 80 kD) in urine. CD59/Protectin antigen was released from the surface of transfected COS cells by phosphatidylinositol-specific phospholipase C, demonstrating that it is attached to the cell membrane by means of a glycolipid anchor; it is therefore likely to be absent from the surface of affected erythrocytes in the disease paroxysmal nocturnal hemoglobinuria.

    CD59a / Protectin Alternative Name

    AA987121,protectin,RP24-297H17.1,Cd59, [human]

    CD59a / Protectin Related Studies

  • Huang Y, et al. (2006) Defining the CD59-C9 binding interaction. J Biol Chem. 281 (37): 27398-404.
  • Sawada R, et al. (1990) Isolation and expression of the full-length cDNA encoding CD59 antigen of human lymphocytes. DNA Cell Biol. 9(3): 213-20.
  • Philbrick WM, et al. (1990) The CD59 antigen is a structural homologue of murine Ly-6 antigens but lacks interferon inducibility. Eur J Immunol. 20(1): 87-92.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"