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Rat CD59 / CD59A / MAC / IP Protein (His Tag)
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Rat CD59 / CD59A / MAC / IP Protein (His Tag) PDF Download

Catalog   Size (Price) Quantity In Stock Operation
80299-R08H  
YES   
 

Protein Production & Purification Service | Recombinant Cytokines & Growth Factors

CD59 molecule, complement regulatory Protein Datasheet

 

CD59 / CD59A / MAC-IP Protein Price Inquiry ( Available Sizes )

CD59 / CD59A / MAC-IP Protein Product Information

Synonym : CD59
Protein Construction:

A DNA sequence encoding the rat CD59 (P27274) (Met1-Asn100) was expressed, fused with a polyhistidine tag at the C-terminus.

Source: Rat
Expression Host: Human Cells

CD59 / CD59A / MAC-IP Protein QC Testing

Purity: > 95% as determined by SDS-PAGE SDS-PAGE:
SDS-PAGE

CD59 / CD59A / MAC-IP protein

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Leu 23
Molecular Mass:

The recombinant rat CD59 /Fc comprises 89 amino acids and has a predicted molecular mass of 10.3 kDa. The apparent molecular mass of the protein is approximately 17 kDa in SDS-PAGE under reducing conditions.

Formulation: Lyophilized from sterile PBS, pH7.4.
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.

CD59 / CD59A / MAC-IP Protein Usage Guide

Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CD59 / CD59A / MAC-IP Protein Related Products & Topics

Related Areas:

Immunology>>Innate Immunity>>Complement System>>CD59

Immunology>>Cluster of Differentiation>>CD59

Proteins:

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
CD59 Human CD59 Protein, Recombinant 12474-H08H
CD59a Mouse CD59a / MAC-IP Protein, Recombinant 50724-M02H
CD59a Mouse CD59a / MAC-IP Protein, Recombinant 50724-M08H
CD59 Rat CD59 / CD59A / MAC-IP Protein, Recombinant 80299-R02H
CD59 Rat CD59 / CD59A / MAC-IP Protein, Recombinant 80299-R08H

Antibodies:

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human
CD59
WB, ELISA Rabbit Polyclonal Antibody (Antigen Affinity Purified) 12474-RP02

CD59 / CD59A / MAC-IP Protein Description

CD59 glycoprotein, also known as 20 kDa homologous restriction factor, HRF20, MAC-inhibitory protein, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, MIC11, MIRL and CD59, is a cell membrane protein which contains one UPAR/Ly6 domain. CD59 is a small, highly glycosylated, GPI-linked protein, with a wide expression profile. The soluble form of CD59 from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. CD59 is a potent inhibitor of the complement membrane attack complex (MAC) action. CD59 was first identified as a regulator of the terminal pathway of complement. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Defects in CD59 are the cause of CD59 deficiency (CD59D).

References

  1. Fletcher CM. et al., 1994, Structure. 2: 185-99.
  2. Rudd PM. et al., 1997, J Biol Chem. 272: 7229-44.
  3. Kimberley FC. et al., 2007, Mol Immunol. 44 (1-3): 73-81.
  4. Gong Y. et al., 2007, Sci China C Life Sci. 50 (6): 773-9.
  5. Picariello G. et al., 2008, Proteomics 8: 3833-47.
  6. Heibeck TH. et al., 2009, J Proteome Res. 8: 3852-61.
 
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"