CD55 Protein & Antibody (DAF)

Cluster of Differentiation 55 (Decay-Accelerating Factor)

CD55 Products

CD55 Protein, Recombinant

Molecule	Species	Description	Cat. No
CD55/DAF	Human	CD55/DAF/Fc Protein, Recombinant	10101-H02H
CD55/DAF	Human	CD55/DAF Protein, Recombinant	10101-H08H
CD55/DAF	Mouse	CD55 / DAF Protein, Recombinant	50468-M08H

  10101-H02H:  Immobilized recombinant human CD97 at 10 µg/ml (100 µl/well) can bind recombinant human CD55 at a linear range of 0.46-30 µg/ml. Measured by its binding ability in a functional ELISA.

  10101-H08H: Immobilized human CD55 at 2 µg/ml (100 µl/well) can bind human CD97 with a linear ranger of 1.28-32 ng/ml. Measured by its binding ability in a functional ELISA.

CD55 Antibody

Molecule	Application	Description	Cat. No
Human CD55/DAF	WB, ELISA	Mouse Monoclonal Antibody	10101-MM03
Human CD55/DAF	WB, FCM	CD55 / DAF Antibody ( FITC )	10101-MM09-F
Human CD55/DAF	WB, ELISA	CD55/DAF Antibody, Rabbit MAb	10101-R028
Human CD55/DAF	WB, ELISA	Rabbit Polyclonal Antibody	10101-RP01

CD55 ELISA Kit

Molecule	Application	Description	Cat. No
Human CD55/DAF	ELISA	CD55/DAF ELISA Kit	SEK10101

CD55 cDNA Clone

Molecule	Species	Description	Cat. No
CD55/DAF	Human	Homo sapiens CD55/DAF transcript variant 1 cDNA Clone(NM_000574.3)	HG10101-M
CD55/DAF	Rat	CD55 cDNA Clone / ORF Clone	RG80317-G

CD55 Related Areas

Immunology>>Innate Immunity>>Complement System>>CD55/DAF

Immunology>>Cluster of Differentiation>>Other>>CD55/DAF

CD55 Alternative Names

CD55, DAF, RP11-357P18.1, CR, CROM, TC [Homo sapiens]

cd55, Daf, AC111067.1, Daf-GPI, Daf1, GPI-DAF [Mus musculus]

CD55 Background

CD55, also well known as decay-accelerating factor (DAF), is a member of the RCA (regulators of complement activation) family characterized by four to 30 SCRs (short consensus repeats) in their plasma-exposed regions. It is a major regulator of the alternative and classical pathways of complement activation and is expressed on all serum-exposed cells. CD55 is physiologically acting as an inhibitor of the complement system, but is also broadly expressed in malignant tumours. DAF seems to exert different functions beyond its immunological role such as promotion of tumorigenesis, decrease of complement mediated tumor cell lysis, autocrine loops for cell rescue and evasion of apoptosis, neoangiogenesis, invasiveness, cell motility. It is commonly hijacked by invading pathogens, including many enteroviruses and uropathogenic Escherichia coli, to promote cellular attachment prior to infection. This 70-75 kDa glycoprotein CD55 containing four SCR modules is involved in the regulation of the complement cascade. It inhibits complement activation by suppressing the function of C3/C5 convertases, thereby limiting local generation or deposition of C3a/C5a and membrane attack complex (MAC or C5b-9) production. DAF has been identified as a ligand for an activation-associated, seven-transmembrane lymphocyte receptor, CD97, which is a receptor mediating attachment and infection of several viruses and bacteria. In addition, it has been shown that DAF regulates the interplay between complement and T cell immunity in vivo, and thus may be implicated in immune and tumor biology.

CD55 Related Studies

1. Lea S. (2002) Interactions of CD55 with non-complement ligands. Biochem Soc Trans. 30(Pt 6): 1014-9.
2. Mikesch JH, et al. (2006) The expression and action of decay-accelerating factor (CD55) in human malignancies and cancer therapy. Cell Oncol. 28(5-6): 223-32.
3. Wang Y, et al. (2010) Decay accelerating factor (CD55) protects neuronal cells from chemical hypoxia-induced injury. J Neuroinflammation. 7:24.