CD54

Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and in animal models of atherosclerosis. Additionally, ICAM-1 has been implicated in the progression of autoimmune diseases. ICAM-1 is a ligand for LFA-1(integrin). When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 interaction and then transmigrate into tissues. Presence with heavy glycosylation and other structural characteristics, ICAM-1 possesses binding sites for a number of immune-associated ligands and serves as the binding site for entry of the major group of human Rhinovirus (HRV) into various cell types. ICAM-1 also becomes known for its affinity for Plasmodium falciparum-infected erythrocytes (PFIE), providing more of a role in infectious disease. Previous studies have shown that ICAM-1 is involved in inflammatory reactions and that a defect in ICAM-1 gene inhibits allergic contact hypersensitivity.

CD54 Related Areas

Cardiovascular>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>ICAM-1/CD54

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Endothelial Cell Marker>>ICAM-1/CD54

Cancer>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>ICAM-1/CD54

Immunology>>Adaptive Immunity>>T Cell>>Regulatory T Cell / T Cell Migration/Adhesion>>ICAM-1/CD54

Immunology>>Adhesion Molecule>> Cell Adhesion Molecule (IgSF CAM) >>ICAM-1/CD54

Immunology>>Cluster of Differentiation>>ICAM-1/CD54

CD54 Alternative Names

ICAM-1, ICAM1, CD54, BB2, P3.58 [Homo sapiens]
Icam-1, Icam1, CD54, Ly-47, MALA-2, MGC6195, myD10 [Mus musculus]

Summaries for CD54

Entrez Gene summary for CD54:

This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor.

OMIM - description for CD54:

CD54 Expression of HLA-DR antigen (see 142860) and CD54 in human conjunctival epithelium is upregulated in patients with dry eyes associated with Sjogren syndrome (270150). Tsubota et al. (1999) reported that this upregulation in Sjogren syndrome patients may be controlled by interferon-gamma (147570) through the activation of transcription factor NFKB (nuclear factor kappa-B; see 164011).

Wikipedia summary for CD54:

ICAM-1 (Intercellular Adhesion Molecule 1) also known as CD54 (Cluster of Differentiation 54) is a protein that in humans is encoded by the ICAM1 gene.[1][2] This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by rhinovirus as a receptor.[

Human CD54 Protein General Information

 

• Protein names: Intercellular adhesion molecule 1, Short name=ICAM-1
• Sequence length: 532 AA.
• Domain: Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
• Sequence similarities: Belongs to the immunoglobulin superfamily. ICAM family. Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
• Post-translational modification: Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.
• Subunit structure: Homodimer Probable. Interacts with human herpesvirus 8 MIR2 protein Probable. Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus.
• Subcellular location: Membrane; Single-pass type I membrane protein.

General information above from UniProt

Function for CD54 Protein

UniProtKB:

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.

Genatlas:

• mediating leukocytes migration into sites of airway inflammation and activation of T cells
• may be playing an important role for endothelial cell migration, through a pathway regulating endothelial nitric-oxide synthase activation and organization of the actin cytoskeleton
• implicated in neutrophil and monocyte-endothelial cell adhesion, processes contributing to myocardial neutrophil infiltration and microvascular coronary slow flow
• on osteoclast precursors manifested as clusters which localized at the baso-lateral membrane
• functions in leukocyte trafficking, activation, and the formation of the immunological synapse
• with VCAM1 were critical for mesenchymal stem cell (MSC)-mediated immunosuppression
• inducible surface glycoprotein that mediates adhesion-dependent cell-to-cell interactions
• AGER and ICAM1 are a new set of functionally linked adhesion molecules, which closely cooperate in mediating leukocyte adhesion during the acute trauma-induced inflammatory response

Homology for human CD54

• homolog to rattus Icam1 (53.31 pc)
• homolog to murine Icam1 (54.25 pc)

Phenotype Information for CD54

Phenotype Information for CD54 from OMIM (Online Mendelian Inheritance in Man)

Drugs for CD54

Target	Drug Name	Disease	Drug Status
CD54	Alicaforsen	Crohn's Disease; Ulcerative colitis	Phase II

Drugs for CD54 from TTD (Therapeutic Targets Database)