Anti-ICAM-1 Antibody

Cat: 50440-R020
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Anti-ICAM-1 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-ICAM-1 Antibody
Validated applications
ELISA,ELISA(Cap),IHC-P
Species reactivity
Reacts with: Mouse
Specificity
Mouse ICAM-1
No cross-reactivity in ELISA with Human ICAM1 Human CD31 Human ICAM3 Human ICAM2 Mouse VCAM1
Immunogen
Recombinant Mouse CD54 / ICAM1 protein (Catalog#50440-M08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD54 / ICAM1 (rM CD54 / ICAM1; Catalog#50440-M08H; NP_034623.1; Met 1-Asn 485).
Source
Monoclonal Rabbit IgG Clone #020
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-ICAM-1 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  
IHC-P 1:100-1:500  
ELISA(Cap) 1:250-1:2000 This antibody will detect Mouse ICAM-1 / CD54 in ELISA pair set (Catalog: # SEK50440). In a sandwich ELISA, it can be used as capture antibody when paired with (Catalog: # 50440-R101).

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-ICAM-1 Antibody (Rabbit Monoclonal antibody) Images
Mouse ICAM-1/CD54 Immunohistochemistry(IHC) 3265
Immunochemical staining of mouse ICAM1 in mouse kidney with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to blood vessel.
Mouse ICAM-1/CD54 Immunohistochemistry(IHC) 3266
Immunochemical staining of mouse ICAM1 in mouse brain with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). The image showing positive staining of choroid plexus.
Anti-ICAM-1 Antibody Alternative Names
Anti-CD54 Antibody;Anti-Icam-1 Antibody;Anti-Ly-47 Antibody;Anti-MALA-2 Antibody
ICAM-1 Background Information

Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and in animal models of atherosclerosis. Additionally, ICAM-1 has been implicated in the progression of autoimmune diseases. ICAM-1 is a ligand for LFA-1(integrin). When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 interaction and then transmigrate into tissues. Presence with heavy glycosylation and other structural characteristics, ICAM-1 possesses binding sites for a number of immune-associated ligands and serves as the binding site for entry of the major group of human Rhinovirus (HRV) into various cell types. ICAM-1 also becomes known for its affinity for Plasmodium falciparum-infected erythrocytes (PFIE), providing more of a role in infectious disease. Previous studies have shown that ICAM-1 is involved in inflammatory reactions and that a defect in ICAM-1 gene inhibits allergic contact hypersensitivity.

Full Name
intercellular adhesion molecule 1
Research Areas
References
  • Xu H, et al. (2001) The role of ICAM-1 molecule in the migration of Langerhans cells in the skin and regional lymph node. Eur J Immunol. 31(10): 3085-93.
  • Terol MJ, et al. (2003) Soluble intercellular adhesion molecule-1 (s-ICAM-1/s-CD54) in diffuse large B-cell lymphoma: association with clinical characteristics and outcome. Ann Oncol. 14(3): 467-74.
  • Mendez MP, et al. (2006) Shedding of soluble ICAM-1 into the alveolar space in murine models of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 290(5): L962-70.
  • Lawson C, et al. (2009) ICAM-1 signaling in endothelial cells. Pharmacol Rep. 61(1): 22-32.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-ICAM-1 Antibody (FITC) Rabbit Monoclonal FCM 80022-R037-F
    Anti-ICAM-1 Antibody Rabbit Monoclonal ELISA(Cap),FCM,ICC/IF,IF 80022-R037
    Anti-ICAM-1 Antibody Rabbit Monoclonal IHC-P 80022-R003
    Anti-ICAM-1 Antibody Rabbit Polyclonal ELISA 80022-RP01
    Anti-ICAM-1 Antibody Rabbit Monoclonal ELISA 80022-R143
    Anti-ICAM-1 Antibody Rabbit Monoclonal ELISA,ELISA(Det) 80022-R112
    Anti-ICAM-1 Antibody Rabbit Polyclonal ELISA,IP 80022-RP02
    Anti-ICAM-1 Antibody (PE) Rabbit Monoclonal FCM 80022-R037-P
    Anti-ICAM-1 Antibody Mouse Monoclonal ELISA 80022-MM11
    Anti-ICAM-1 Antibody (APC) Rabbit Monoclonal FCM 80022-R037-A
    Anti-ICAM-1 Antibody Rabbit Polyclonal WB,ELISA,IHC-P,IP 80022-T60
    Anti-ICAM-1 Antibody Rabbit Monoclonal IHC-P 50440-R280
    Anti-ICAM-1 Antibody Rabbit Polyclonal ELISA,IHC-P 50440-T24
    Anti-ICAM-1 Antibody Rabbit Polyclonal ELISA 50440-RP01
    Anti-ICAM-1 Antibody Rabbit Monoclonal ELISA(Det) 50440-R101
    Anti-ICAM-1 Antibody Rabbit Monoclonal FCM 50440-R009
    Anti-ICAM-1 Antibody (PE) Rabbit Monoclonal FCM 50440-R009-P
    Anti-ICAM-1 Antibody (FITC) Rabbit Monoclonal FCM 50440-R009-F
    Anti-ICAM-1 Antibody Rabbit Polyclonal ELISA,IHC-P 50440-RP02
    Anti-ICAM-1 Antibody Rabbit Polyclonal ELISA 10346-T16
    Anti-ICAM-1 Antibody (PE) Mouse Monoclonal FCM 10346-MM01-P
    Anti-ICAM-1 Antibody (PerCP) Mouse Monoclonal FCM 10346-MM01-C
    Anti-ICAM-1 Antibody (FITC) Mouse Monoclonal FCM 10346-MM01-F
    Anti-ICAM-1 Antibody Mouse Monoclonal ELISA,ELISA(Cap),FCM,ICC/IF,IF 10346-MM01
    Anti-ICAM-1 Antibody Mouse Monoclonal ELISA 10346-MM04
    Anti-ICAM-1 Antibody (APC) Mouse Monoclonal FCM 10346-MM01-A
    Anti-ICAM-1 Antibody Mouse Monoclonal WB 10346-MM03
    Anti-ICAM-1 Antibody Rabbit Polyclonal ELISA,IHC-P,ICC/IF,IF 10346-T26
    Anti-ICAM-1 Antibody Rabbit Polyclonal WB,ELISA,IHC-P,IP 10346-RP02
    Anti-ICAM-1 Antibody Rabbit Monoclonal ELISA 10346-R013
    Anti-ICAM-1 Antibody Rabbit Polyclonal ELISA 10346-RP01
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