- EGFR Signaling Pathway
- TGF-beta Signaling
- Canonical Wnt Signaling
- non-Canonical Wnt Signaling
- Notch Signaling
- p53 Pathway
- NF-kB Pathway
- Cytokine Signaling
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Cd5 molecule Protein Datasheet
CD5 Protein Price Inquiry ( Available Sizes )
CD5 Protein Product Information
A DNA sequence encoding the rat CD5 (P51882) (Met1-Pro368) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
|Expression Host:||Human Cells|
CD5 Protein QC Testing
|Purity:||> 95% as determined by SDS-PAGE||SDS-PAGE:
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Gly 24|
The recombinant rat CD5/Fc is a disulfide-linked homodimer. The reduced monomer comprises 586 amino acids and has a predicted molecular mass of 64.5 kDa. The apparent molecular mass of the protein is approximately 85 kDa in SDS-PAGE under reducing conditions.
|Formulation:||Lyophilized from sterile PBS, pH7.4.
CD5 Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
CD5 Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|CD5||Human||CD5 Protein, Recombinant||11027-H08H|
|CD5||Mouse||CD5 Protein, Recombinant||50403-M08H|
|CD5||Rat||CD5 Protein, Recombinant||80374-R02H|
|CD5||Rat||CD5 Protein, Recombinant||80374-R08H|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|WB, ELISA||Mouse Monoclonal Antibody||11027-MM05|
|WB, ELISA||CD5 Antibody, Rabbit MAb||50403-R105|
|WB, ELISA||CD5 Antibody||11027-RP01|
|WB, ELISA, IHC-P||CD5 Antibody (Antigen Affinity Purified)||11027-RP02|
|WB, ELISA||Rabbit Polyclonal Antibody||50403-RP01|
|WB, ELISA, IHC-P||Rabbit Polyclonal Antibody (Antigen Affinity Purified)||50403-RP02|
CD5 Protein Description
T-cell surface glycoprotein CD5, also known as Lymphocyte antigen T1 and LEU1, is a single-pass type I membrane protein. CD5 contains 3 SRCR domains and has been regarded as a possible B cell lineage marker differentiating subsets, CD5+ B cells (also termed B1 cells) and conventional B cells (or B2 cells). CD5 is expressed at various developmental and activation stages on human B cells. It is a well established negative regulator of TCR and BCR signalling. Increased expression of CD5 on either T cells or B cells protects against autoimmunity. CD5-positive cells may also prevent the emergence of autoimmunity by provision of cytokines such as IL-10. The physiological role of CD5 might be to control the generation of aberrant immune responses. In cancers, CD5 expression plays a role in the fate of tumour-specific T cells, rendering lymphocytes tolerant and unable to recognize and eliminate malignant cells. Development, selection and function of different B- and T-cell subsets or their preferential survival may be directly or indirectly dependent on different glycan structures associated with CD5 or CD5-like molecules.
- Heuring AH. et al., 2001, The British journal of ophthalmology. 85 (4): 498-9.
- Dalloul A. 2009, Autoimmun Rev. 8 (4): 349-53.
- Pospisil R. et al., 2009, Mol Immunol. 46 (13): 2456-64.