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Rat CD5 Protein (His Tag)
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Rat CD5 Protein (His Tag) PDF Download

Catalog   Size (Price) Quantity In Stock Operation
80374-R08H  
YES   
 

Protein Production & Purification Service | Recombinant Cytokines & Growth Factors

Cd5 molecule Protein Datasheet

 

CD5 Protein Price Inquiry ( Available Sizes )

CD5 Protein Product Information

Synonym : CD5
Protein Construction:

A DNA sequence encoding the rat CD5(P51882)(Met1-Pro368) was expressed, fused with a polyhistidine tag at the C-terminus.

Source: Rat
Expression Host: Human Cells

CD5 Protein QC Testing

Purity: > 95 % as determined by SDS-PAGE SDS-PAGE:
SDS-PAGE

CD5 protein

Bio-activity:

Immobilized rat CD5-His at 10 μg/ml (100 μl/well) can bind biotinylated human GST-LCK (Cat:10043-H09B), The EC50 of biotinylated human GST-LCK (Cat:10043-H09B) is 0.9-2.1 μg/ml.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Gln 24
Molecular Mass:

The recombinant rat CD5 comprises 356 amino acids and predicts a molecular mass of 38.9 kDa. The apparent molecular mass of  the recombinant protein is approximately 46-49 kDa in SDS-PAGE under reducing conditions due to glycosylation.

Formulation: Lyophilized from sterile PBS, pH7.4.
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.

CD5 Protein Usage Guide

Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CD5 Protein Related Products & Topics

Related Areas:

Immunology>>Adaptive Immunity>>T Cell>>Regulatory T Cell>>CD5

Immunology>>Innate Immunity>>Monocyte/Macrophage>>Scavenger Receptor>>CD5

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD5

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Regulatory T Cells>>CD5

Cardiovascular>>Lipid Metabolism>>Scavenger Receptor>>CD5

Proteins:

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
CD5 Human CD5 Protein, Recombinant 11027-H08H
CD5 Mouse CD5 Protein, Recombinant 50403-M08H
CD5 Rat CD5 Protein, Recombinant 80374-R02H
CD5 Rat CD5 Protein, Recombinant 80374-R08H

Antibodies:

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human
CD5
WB, ELISA Mouse Monoclonal Antibody 11027-MM05
Mouse
CD5
WB, ELISA CD5 Antibody, Rabbit MAb 50403-R105
Human
CD5
WB, ELISA CD5 Antibody 11027-RP01
Human
CD5
WB, ELISA, IHC-P CD5 Antibody (Antigen Affinity Purified) 11027-RP02
Mouse
CD5
WB, ELISA Rabbit Polyclonal Antibody 50403-RP01
Mouse
CD5
WB, ELISA, IHC-P Rabbit Polyclonal Antibody (Antigen Affinity Purified) 50403-RP02
Mouse
CD5
FCM CD5 Antibody 50403-R114-F

CD5 Protein Description

T-cell surface glycoprotein CD5, also known as Lymphocyte antigen T1 and LEU1, is a single-pass type I  membrane protein. CD5 contains 3 SRCR domains and has been regarded as a possible B cell lineage marker differentiating subsets, CD5+ B cells (also termed B1 cells) and conventional B cells (or B2 cells). CD5 is expressed at various developmental and activation stages on human B cells. It is a well established negative regulator of TCR and BCR signalling. Increased expression of CD5 on either T cells or B cells protects against autoimmunity. CD5-positive cells may also prevent the emergence of autoimmunity by provision of cytokines such as IL-10. The physiological role of CD5 might be to control the generation of aberrant immune responses. In cancers, CD5 expression plays a role in the fate of tumour-specific T cells, rendering lymphocytes tolerant and unable to recognize and eliminate malignant cells. Development, selection and function of different B- and T-cell subsets or their preferential survival may be directly or indirectly dependent on different glycan structures associated with CD5 or CD5-like molecules.

References

  1. Heuring AH. et al., 2001, The British journal of ophthalmology. 85 (4): 498-9.
  2. Dalloul A. 2009, Autoimmun Rev. 8 (4): 349-53.
  3. Pospisil R. et al., 2009, Mol Immunol. 46 (13): 2456-64.
 
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"