CD5 (Protein | Antibody | cDNA Clone | ELISA Kit)

All CD5 reagents are produced in house and quality controlled, including 40 CD5 Antibody, 1 CD5 ELISA, 52 CD5 Gene, 1 CD5 IP Kit, 5 CD5 Lysate, 5 CD5 Protein, 3 CD5 qPCR. All CD5 reagents are ready to use.

CD5 Protein (5)

CD5 Antibody (40)

CD5 ELISA Kit & Match Antibody ELISA Pair Set (1)

CD5 cDNA Clone (52)

NM_014207.3
NM_007650.3
NM_019295.1
XM_001083880.2

CD5 Lysate (5)

CD5 Background

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 32 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD5 is a member of the CD system. CD5 was found to be widely distributed in T-cells and B1 cells which is a subset of IgM-secreting B cells. CD5 also was found expressed in small lymphocytic lymphoma, hairy cell leukaemia and mantle cell lymphoma cells. CD5 serves to weaken the activating stimulus from the BCR so that the B1 cells can only reflect to the very strong stimuli but not the normal tissue proteins.

CD5 References

  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters. 134 (2): 104-12.
  • Kirchgessner H, et al. (2001) The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain. J Exp Med. 193 (11): 1269-84.