CD5 Protein & Antibody (Ly-1, Lyt-1)

Cluster of Differentiation 5 (Lymphocyte antigen 1)

CD5 Products

CD5 Protein, Recombinant

Molecule	Species	Description	Cat. No
CD5	Human	CD5 Protein, Recombinant	11027-H08H
CD5	Mouse	CD5 Protein, Recombinant	50403-M08H

CD5 Antibody

Molecule	Application	Description	Cat. No
Human CD5	WB, ELISA	Mouse Monoclonal Antibody	11027-MM05
Mouse CD5	WB, ELISA	CD5 Antibody, Rabbit MAb	50403-R105
Human CD5	WB, ELISA	CD5 Antibody	11027-RP01
Human CD5	WB, ELISA, IHC-P	CD5 Antibody (Antigen Affinity Purified)	11027-RP02
Mouse CD5	WB, ELISA	Rabbit Polyclonal Antibody	50403-RP01
Mouse CD5	WB, ELISA, IHC-P	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	50403-RP02

CD5 cDNA Clone

Molecule	Species	Description	Cat. No
CD5	Human	Homo sapiens CD5 cDNA Clone(NM_014207.2)	HG11027-M
CD5	Mouse	Mus musculus CD5 cDNA Clone	MG50403-M
CD5	Rat	CD5 cDNA Clone / ORF Clone	RG80374-G

CD5 Related Areas

Immunology>>Adaptive Immunity>>T Cell>>Regulatory T Cell>>CD5

Immunology>>Innate Immunity>>Monocyte/Macrophage>>Scavenger Receptor>>CD5

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD5

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Regulatory T Cells>>CD5

Cardiovascular>>Lipid Metabolism>>Scavenger Receptor>>CD5

CD5 Alternative Names

CD5, LEU1, T1 [Homo sapiens]

Cd5, Ly-1, Ly-12, Ly-A, Lyt-1 [Mus musculus]

CD5 Background

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD5 is a member of the CD system. CD5 was found to be widely distributed in T-cells and B1 cells which is a subset of IgM-secreting B cells. CD5 also was found expressed in small lymphocytic lymphoma, hairy cell leukaemia and mantle cell lymphoma cells. CD5 serves to weaken the activating stimulus from the BCR so that the B1 cells can only reflect to the very strong stimuli but not the normal tissue proteins.

CD5 Related Studies

1. Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
2. Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125–35.
3. Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters. 134 (2): 104-12.
4. Kirchgessner H, et al. (2001) The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain. J Exp Med. 193 (11): 1269–84.