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Mouse CD5 ELISA Pair Set
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Mouse CD5 ELISA Pair Set PDF Download

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SEK50403  

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Mouse CD5 ELISA Pair Set

Order or Inquire for CD5 ELISA Pair Set
High affinity Mouse CD5 ELISA Pair Set
Detection limit - 12.5 pg/ml
Affordable price and 30%-80% cost saving for Bulk order
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Background

T-cell surface glycoprotein CD5, also known as Lymphocyte antigen T1 and LEU1, is a single-pass type I membrane protein. CD5 contains 3 SRCR domains and has been regarded as a possible B cell lineage marker differentiating subsets, CD5+ B cells (also termed B1 cells) and conventional B cells (or B2 cells). CD5 is expressed at various developmental and activation stages on human B cells. It is a well established negative regulator of TCR and BCR signalling. Increased expression of CD5 on either T cells or B cells protects against autoimmunity. CD5-positive cells may also prevent the emergence of autoimmunity by provision of cytokines such as IL-10. The physiological role of CD5 might be to control the generation of aberrant immune responses. In cancers, CD5 expression plays a role in the fate of tumour-specific T cells, rendering lymphocytes tolerant and unable to recognize and eliminate malignant cells. Development, selection and function of different B-cell and T-cell subsets or their preferential survival may be directly or indirectly dependent on different glycan structures associated with CD5 or CD5-like molecules. CD5(+) B cells increase physiologically during mouse adolescence, and subsequently decrease with aging.

 
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