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CD48/SLAMF2 Protein, Antibody, ELISA Kit, cDNA Clone

Description: Active
Expression host: Human Cells
  • Slide 1
10797-H08H-50
10797-H08H-100
50 µg / $178
100 µg / $298
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Expression host: Human Cells
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10797-H02H-50
10797-H02H-100
50 µg / $178
100 µg / $298
Add to Cart
Description: Active
Expression host: Human Cells
  • Slide 1
50415-M08H-50
50415-M08H-100
50 µg / $178
100 µg / $298
Add to Cart
Expression host: Human Cells
  • Slide 1
50415-M02H-50
50415-M02H-100
50 µg / $178
100 µg / $298
Add to Cart
Expression host: Human Cells
  • Slide 1
80286-R08H-50
80286-R08H-100
50 µg / $178
100 µg / $298
Add to Cart
Expression host: Human Cells
  • Slide 1
80286-R02H-50
80286-R02H-100
50 µg / $178
100 µg / $298
Add to Cart

CD48/SLAMF2 Related Areas

CD48/SLAMF2 Related Pathways

CD48/SLAMF2 Related Product

    CD48/SLAMF2 Summary & Protein Information

    CD48/SLAMF2 Background

    Gene Summary: This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
    General information above from NCBI
    Subunit structure: Interacts with CD244 in an heterophilic manner (By similarity).
    Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor.
    Sequence similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.C
    General information above from UniProt

    Cluster of Differentiation 48 (CD48), also known as SLAMF2, BCM-1 and BLAST-1, is a GPI-linked protein belonging to the CD2 subfamily of immunoglobulin superfamily molecules. CD2 and 2B4 (CD244) are known ligands for CD48. CD48 protein is expressed on most lineage-committed hematopoietic cells but not on hematopoietic stem cells or multipotent hematopoietic progenitors. CD48 protein performs biological functions in a variety processes including adhesion, pathogen recognition, cellular activation, and cytokine regulation, and emerges as a critical effector molecule in immune responses.

    CD48/SLAMF2 Alternative Name

    BCM1,BLAST,BLAST1,CD48,hCD48,mCD48,MEM-102,SLAMF2, [human]
    AI449234,AW610730,BCM1,Bcm-1,BLAST,BLAST1,BLAST-1,Cd48,MEM-102,Sgp-60,SLAMF2, [mouse]

    CD48/SLAMF2 Related Studies

  • Messmer B, et al. (2006) CD48 stimulation by 2B4 (CD244)-expressing targets activates human NK cells. J Immunol. 176(8): 4646-50
  • Milstein O, et al. (2008) Nanoscale increases in CD2-CD48-mediated intermembrane spacing decrease adhesion and reorganize the immunological synapse. J Biol Chem. 283(49): 34414-22.
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