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CD48 / SLAMF2 / BCM1 Antibody, Rabbit MAb

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    Mouse CD48 Antibody Product Information
    Immunogen:Recombinant Mouse CD48 protein (Catalog#50415-M08H)
    Clone ID:009
    Ig Type:Rabbit IgG
    Concentration:
    Endotoxin:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD48 (rM CD48; Catalog#50415-M08H; Met 1-Arg 216; NP_031675.1).
    Other CD48 Antibody Products
    CD48/Blast-1 Background

    Cluster of Differentiation 48 (CD48), also known as SLAMF2, BCM-1 and BLAST-1, is a GPI-linked protein belonging to the CD2 subfamily of immunoglobulin superfamily molecules. CD2 and 2B4 (CD244) are known ligands for CD48. CD48 protein is expressed on most lineage-committed hematopoietic cells but not on hematopoietic stem cells or multipotent hematopoietic progenitors. CD48 protein performs biological functions in a variety processes including adhesion, pathogen recognition, cellular activation, and cytokine regulation, and emerges as a critical effector molecule in immune responses.

    Immune Checkpoint
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    Immune Checkpoint Proteins
    Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

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    Mouse CD48/Blast-1 References
  • Messmer B, et al. (2006) CD48 stimulation by 2B4 (CD244)-expressing targets activates human NK cells. J Immunol. 176(8): 4646-50
  • Milstein O, et al. (2008) Nanoscale increases in CD2-CD48-mediated intermembrane spacing decrease adhesion and reorganize the immunological synapse. J Biol Chem. 283(49): 34414-22.
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