Anti-CD46 Antibody

Cat: 12239-MM06
Contact us:
+86-400-890-9989
order@sinobiological.com
Distributors
All CD46 Reagents
CRO Services

All CD46 Reagents
Anti-CD46 Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-CD46 Antibody
Validated applications
WB
Species reactivity
Reacts with: Human
Specificity
Human CD46
No cross-reactivity in ELISA with Human cell lysate (293 cell line)
Immunogen
Recombinant Human CD46 protein (Catalog#12239-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD46 (rh CD46; Catalog#12239-H08H; EAW93471.1; Met 1-Asp 328). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #5H5C5D1
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CD46 Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
WB 1-2 μg/mL  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD46 Antibody Alternative Names
Anti-AHUS2 Antibody;Anti-MCP Antibody;Anti-MIC10 Antibody;Anti-TLX Antibody;Anti-TRA2.10 Antibody
CD46 Background Information

CD46, also known as Membrane Cofactor Protein (MCP), is a complement regulatory protein. CD46 is a type 1 membrane protein that plays an important inhibitory role in the complement system. CD46 is expressed in white blood cells, platelets, epithelial cells, and fibroblasts. Human CD46 shares 50% amino acid sequence identity with mouse and rat CD46. The importance of CD46 to complement regulation is underscored by the observation that genetic loss of CD46 leads to development of atypical hemolytic-uremic syndrome (aHUS), a disease characterized by uncontrolled complement activation. CD46 is implicated in the development and/or progression of selected cancer types.

Full Name
CD46 molecule, complement regulatory protein
References
  • Lublin D.M., et al.,(1988), Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins. J. Exp. Med. 168:181-194.
  • Purcell D.F., et al., (1991), Alternatively spliced RNAs encode several isoforms of CD46 (MCP), a regulator of complement activation.Immunogenetics 33:335-344.
  • Post T.W., et al.,(1991), Membrane cofactor protein of the complement system: alternative splicing of serine/threonine/proline-rich exons and cytoplasmic tails produces multiple isoforms that correlate with protein phenotype.J. Exp. Med. 174:93-102.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CD46 Antibody Rabbit Polyclonal ELISA 12239-RP01
    Anti-CD46 Antibody Rabbit Polyclonal WB,ELISA,IHC-P,IP 12239-RP02
    Anti-CD46 Antibody (PE) Mouse Monoclonal FCM 12239-MM05-P
    Anti-CD46 Antibody Mouse Monoclonal FCM,ICC/IF,IF 12239-MM05
    Anti-CD46 Antibody Rabbit Monoclonal ELISA,IHC-P,ICC/IF,IF 12239-R001
    Anti-CD46 Antibody (APC) Mouse Monoclonal FCM 12239-MM05-A
    Anti-CD46 Antibody Mouse Monoclonal ELISA,IHC-P 12239-MM01
    Anti-CD46 Antibody (FITC) Mouse Monoclonal FCM 12239-MM05-F
    info info
    添加购物车成功! 添加购物车失败!