CD45 Protein & Antibody

Cluster of Differentiation 45

CD45 Products

CD45 Protein, Recombinant

Molecule	Species	Description	Cat. No
CD45	Human	CD45/Fc Protein, Recombinant	10086-H02H

CD45 Antibody

Molecule	Application	Description	Cat. No
Human CD45	FCM	CD45 Antibody ( FITC )	10086-MM05-F

CD45 cDNA Clone

Molecule	Species	Description	Cat. No
CD45	Human	Homo sapiens CD45 transcript variant 2 cDNA Clone	HG10086-M

CD45 Related Areas

Enzyme>>Phosphatase & Regulator>>CD45

Signal Transduction>>Phosphatase & Regulator>>CD45

Stem Cell>>Mesenchymal Stem Cell (MSC)>>Mesenchymal Stem Cell Marker>>CD45

Stem Cell>>Mesenchymal Stem Cell (MSC)>>Osteoblast & Osteoclast Marker>>CD45

Cancer>>Cancer Stem Cell (CSC)>>CD45

Immunology>>Adaptive Immunity>>T Cell>>Regulatory T Cell / T Cell Antigen Recognition / T Cell Migration/Adhesion>>CD45

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD45

Immunology>>Cluster of Differentiation>>Dendritic Cell CD Antigen>>Dendritic Cell Adhesion>>CD45

Immunology>>Cluster of Differentiation>>Dendritic Cell CD Antigen>>Dendritic Cell Pathogen Recognition/Uptake>>CD45

Immunology>>Cluster of Differentiation>>Granulocyte CD Antigen>>Basophils / Granulocyte Markers / Eosinophils>>CD45

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers / Monocyte Markers>>CD45

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Regulatory T Cells / T Cell Antigen Recognition / T Cell Migration/Adhesion>>CD45

CD45 Alternative Names

CD45, PTPRC, B220, CD45R, GP180, LCA, LY5, RP11-553K8.4, T200 [Homo sapiens]

Cd45, Ptprc, B220, CD45R, Ly-5, Lyt-4, T200, loc, L-CA [Mus musculus]

CD45 Background

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Protein tyrosine phosphatase, receptor type C (CD45), also known as PTPRC is a member of the protein tyrosine phosphatase (PTP) family which is known for its function to serve as signaling molecules and to regulate a variety of cellular processes such as cell proliferation, differentiation, mitotic cycle and oncogenic transformation. CD45 is found expression specifically in hemotopietic cells. CD45 consists of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. It serves as an essential regulator of T-cell and B-cell antigen receptor signaling through either direct interaction with components of the antigen receptor complexs or by activating various Src family kinases required for the antigen receptor signaling and it also can suppress JAK kinases.

CD45 Related Studies

1. Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
2. Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125–35.
3. Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
4. Irie-Sasaki J, et al. (2001) CD45 is a JAK phosphatase and negatively regulates cytokine receptor signaling. Nature. 409: 349-54.