All CD45 reagents are produced in house and quality controlled, including 13 CD45 Antibody, 54 CD45 Gene, 4 CD45 Lysate, 4 CD45 Protein, 3 CD45 qPCR. All CD45 reagents are ready to use.
Recombinant CD45 proteins are expressed by Baculovirus-Insect Cells, HEK293 Cells with fusion tags as N-GST & His, C-cleavage, C-human IgG1-Fc.
CD45antibodies are validated with different applications, which are IHC-P, FCM, ELISA.
CD45cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each CD45 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Expression host: Baculovirus-Insect Cells
The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Protein tyrosine phosphatase, receptor type C (CD45), also known as PTPRC is a member of the protein tyrosine phosphatase (PTP) family which is known for its function to serve as signaling molecules and to regulate a variety of cellular processes such as cell proliferation, differentiation, mitotic cycle and oncogenic transformation. CD45 is found expression specifically in hemotopietic cells. CD45 consists of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. It serves as an essential regulator of T-cell and B-cell antigen receptor signaling through either direct interaction with components of the antigen receptor complexs or by activating various Src family kinases required for the antigen receptor signaling and it also can suppress JAK kinases.