CD40L / CD154 Protein (TNFSF5 Protein)

CD40 Ligand / Cluster of Differentiation 154 (Tumor necrosis factor (ligand) superfamily member 5)

CD40L / CD154 Products

CD40L / CD154 Protein, Recombinant

Molecule	Species	Description	Cat. No
CD40L/CD154/TNFSF5	Human	CD40L/CD154/TNFSF5 Protein, Recombinant	10239-H01H
CD40L/CD154/TNFSF5	Human	CD40L/CD154/TNFSF5 Protein, Recombinant	10239-H08E
CD40L/CD154/TNFSF5	Mouse	CD40L / CD154 / TNFSF5 Protein, Recombinant	50327-M01H

  10239-H01H: Immobilized human CD40 at 2 µg/ml (100 µl/well) can bind human CD40L Fc Chimera with a linear ranger of 1.28-32 ng/ml. Measured by its binding ability in a functional ELISA.

  10239-H08E:

1. Immobilized human CD40 at 2 µg/ml (100 µl/well) can bind biotinylated human CD40L with a linea range of 15.6-500 ng/ml. Measured by its binding ability in a functional ELISA.

2. Immobilized human CD40/Fc at 2 µg/ml (100 µl/well) can bind biotinylated human CD40L with a linear range of 7.8-125 ng/ml. Measured by its binding ability in a functional ELISA.

CD40L / CD154 cDNA Clone

Molecule	Species	Description	Cat. No
CD40L/CD154/TNFSF5	Human	CD40L/TNFSF5 cDNA Clone / ORF Clone	HG10239-M
CD40L/CD154/TNFSF5	Mouse	CD40L/TNFSF5 cDNA Clone	MG50327-M
CD40L/CD154/TNFSF5	Rat	CD40LG cDNA Clone / ORF Clone	RG80151-G
CD40L/CD154/TNFSF5	Cynomolgus	CD40LG cDNA Clone / ORF Clone	KG90096-G

CD40L / CD154 Related Areas

Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>CD40L/CD154/TNFSF5

Immunology>>Adaptive Immunity>>T Cell>>Regulatory T Cell>>CD40L/CD154/TNFSF5

Immunology>>Cytokine & Receptor>>TNF Superfamily>>CD40L/CD154/TNFSF5

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells / Regulatory T Cells>>CD40L/CD154/TNFSF5

CD40L / CD154 Alternative Names

CD40L, CD154, TNFSF5, RP3-527F8.3, CD40LG, HIGM1, IGM, IMD3, T-BAM, TRAP, gp39, hCD40L [Homo sapiens]

Cd40l, CD154, Tnfsf5, RP23-153G22.3, Cd40lg, HIGM1, IGM, IMD3, Ly-62, Ly62, T-BAM, TRAP, gp39 [Mus musculus]

CD40L / CD154 Background

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD154, also known as CD40 ligand or CD40L, is a member of the TNF superfamily. While CD154 was originally found on T cell surface, its expression has since been found on a wide variety of cells, including platelets, mast cells, macrophages and NK cells. CD154's ability is achieved through binding to the CD40 on antigen- presenting cells (APC). In the macrophage cells, the primary signal for activation is IFN-γ from Th1 type CD4 T cells. The secondary signal is CD40L on the T cell, which interacting with the CD40 molecules, helping increase the level of activation.

CD40L / CD154 Related Studies

1. Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
2. Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125–35.
3. Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
4. Grewal IS, et al. (1998) CD40 and CD154 in cell-mediated immunity. Annual Review of Immunology. 16: 111-35.